96349-58-5Relevant articles and documents
1,4-Addition of TMSCCl3 to (E)-Fumaric Esters and Thermal Rearrangement of the Adducts to 3,4-Dichloropent-2-enedioates
Wahl, Benoit,Lee, Darren S.,Woodward, Simon
, p. 6033 - 6039 (2015)
The diesters (E)-RO2CCH=CHCO2R [R = Et, CH2Ph, iPr, iBu, tBu, 2-ethylhexyl, (-)-menthyl, (-)-bornyl] undergo 1,4-trichloromethylation with Me3SiCCl3 in 84-95% yield with Bu4NX (X = OAc, Cl,
One-Carbon Homologation of Primary Alcohols and the Reductive Homologation of Aldehydes Involving a Jocic-Type Reaction
Li, Zhexi,Gupta, Manoj K.,Snowden, Timothy S.
, p. 7009 - 7019 (2015/11/16)
(Trichloromethyl)carbinols, which are formed in one operation from either alcohols or aldehydes, can be converted into primary alcohols in a Jocic-type reaction involving LiBH4. The net result is a convenient two-step, one-carbon homologation of primary alcohols or a reductive one-carbon homologation of aldehydes featuring a broad substrate scope. The method is step-economical, and it nicely complements established one-carbon homologation strategies. (Trichloromethyl)carbinols, which are formed in one operation from either alcohols or aldehydes, can be converted into primary alcohols in a Jocic-type reaction involving LiBH4. The net result is a convenient two-step, one-carbon homologation of primary alcohols or a reductive one-carbon homologation of aldehydes featuring a broad substrate scope.
Decarboxylative trichloromethylation of aromatic aldehydes and its applications in continuous flow
Jensen, Andreas B.,Lindhardt, Anders T.
, p. 1174 - 1183 (2014/03/21)
Two new protocols for the efficient synthesis of 2,2,2- trichloromethylcarbinols, starting from aromatic aldehydes, have been developed. A combination of sodium trichloroacetate in the presence of malonic acid proved efficient for the transformation of el
