96436-58-7

Basic information

• Product Name: 2-Propenal, 3-(4-amino-2-oxo-1(2H)-pyrimidinyl)-, (E)-
• CAS NO: 96436-58-7
• Molecular Formula: C7H7N3O2
• Molecular Weight: 165.151
• Mol File: 96436-58-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Propenal, 3-(4-amino-2-oxo-1(2H)-pyrimidinyl)-, (E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenal, 3-(4-amino-2-oxo-1(2H)-pyrimidinyl)-, (E)-(96436-58-7)
• EPA Substance Registry System: 2-Propenal, 3-(4-amino-2-oxo-1(2H)-pyrimidinyl)-, (E)-(96436-58-7)

Safety Data

• Hazardous Substances Data: 96436-58-7(Hazardous Substances Data)

Upstream product

• 71203-50-4 C₅₇H₇₄N₂₄O₃₇P₆ 

Relevant articles and documents

Identification and quantitation of the lesion accompanying base release in bleomycin-mediated DNA degradation

Interaction of bleomycin, Fe2+, and limiting O2 or bleomycin, Fe3+, and H2O2 with DNA results in the production of free nucleic acid base and an oxidatively damaged sugar lesion that undergoes strand scission subsequent to treatment with alkali. The hexamer d(CGCGCG) has been utilized to develop a protocol to establish the identity of this lesion as a 2'-deoxy-4'-pentulose moiety and to establish its stoichiometric production with respect to free nucleic acid base. The protocol developed has been extended to a variety of heterogeneous DNAs with similar results. The predominant pathway for base release in bleomycin-mediated DNA degradation is the result of chemistry at the C-4' carbon of the sugar moiety.