96507-72-1

Basic information

• Product Name: ethyl 4-chloro-3-formyl-5,6-dihydro-2H-pyridine-1-carboxylate
• Synonyms: ethyl 4-chloro-3-formyl-5,6-dihydro-2H-pyridine-1-carboxylate;4-Chloro-3-formyl-5,6-dihydro-1(2H)-pyridinecarboxylic acid ethyl ester;4-chloro-3-formyl-5,6-dihydro-2H-pyridine-1-carboxylic acid ethyl ester;ethyl 4-chloro-3-methanoyl-5,6-dihydro-2H-pyridine-1-carboxylate;ethyl 4-chloro-5-formyl-3,6-dihydropyridine-1(2H)-carboxylate;4-Chloro-5-formyl-3,6-dihydro-2H-pyridine-1-carboxylic acid ethyl ester
• CAS NO: 96507-72-1
• Molecular Formula: C₉H₁₂ClNO₃
• Molecular Weight: 217.64948
• EINECS: 306-150-6
• Mol File: 96507-72-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 318.8°Cat760mmHg
• Flash Point: 146.6°C
• Appearance: /
• Density: 1.27g/cm³
• Vapor Pressure: 0.000353mmHg at 25°C
• Refractive Index: 1.521
• CAS DataBase Reference: ethyl 4-chloro-3-formyl-5,6-dihydro-2H-pyridine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-chloro-3-formyl-5,6-dihydro-2H-pyridine-1-carboxylate(96507-72-1)
• EPA Substance Registry System: ethyl 4-chloro-3-formyl-5,6-dihydro-2H-pyridine-1-carboxylate(96507-72-1)

Safety Data

• Hazardous Substances Data: 96507-72-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H12ClNO3/c1-2-14-9(13)11-4-3-8(10)7(5-11)6-12/h6H,2-5H2,1H3

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 29976-53-2 N-ethoxycarbonyl-4-piperidone 

Downstream Products

• 54903-50-3 4,5,6,7-tetrahydrothieno[3,2-c]pyridine 
• 116118-98-0 4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylic acid 
• 116119-00-7 6,7-Dihydro-4H-thieno[3,2-c]pyridine-2,5-dicarboxylic acid diethyl ester 

Relevant articles and documents

Efficient synthesis of 4- And 5-substituted 2-aminopyrimidines by coupling of β-Chlorovinyl Aldehydes and Guanidines

A general, practical, and simple synthesis of functionalized 2-aminopyrimidines starting from β-chlorovinyl aldehydes and amidines is reported. In the presence of potassium carbonate, various ketones have been efficiently transformed into the pyrimidine derivatives by a two-step sequence involving the Vilsmeier-Haack reaction followed by a condensation reaction with guanidines. The protocol is distinguished by operational simplicity, inexpensive reagents, and functional-group tolerance. In many cases, pure solid products can be obtained in high to excellent yields without using column chromatography. The synthetic value of the method was demonstrated by the efficient synthesis of steroidal pyrimidines and a precursor of the antitumor agents Imatinib and Mocetinostat.

SUBSTITUTED SULFONAMIDE DERIVATIVES

The invention relates to substituted sulfonamide derivatives, processes for the preparation thereof, medicaments containing these compounds and the use of substituted sulfonamide derivatives for the preparation of medicaments.