96514-70-4

Basic information

• Product Name: 2,3-bis(4-chlorophenyl)-3-oxopropanenitrile
• Synonyms: 2,3-bis(4-chlorophenyl)-3-oxopropanenitrile
• CAS NO: 96514-70-4
• Molecular Weight: 290.149
• Mol File: 96514-70-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,3-bis(4-chlorophenyl)-3-oxopropanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-bis(4-chlorophenyl)-3-oxopropanenitrile(96514-70-4)
• EPA Substance Registry System: 2,3-bis(4-chlorophenyl)-3-oxopropanenitrile(96514-70-4)

Safety Data

• Hazardous Substances Data: 96514-70-4(Hazardous Substances Data)

Upstream product

• 7335-27-5 ethyl 4-chlorobenzoate 
• 140-53-4 p-chlorobenzyl cyanide 

Relevant articles and documents

Synthesis and cytotoxicity of amino-pyrazole derivatives with preliminary SAR

In this in vitro study, a series of amino-pyrazole derivatives were designed, synthesized, and evaluated against five human cancer cell lines (PC3, A549, HL60, HCT116, and SW620) for their anti-proliferative effects and inhibition of p53-MDM2 binding. The results of the biological evaluation showed that this series of compounds has improved inhibition of p53-MDM2 binding and anti-proliferative activities compared to previously designed pyrazole derivatives. Compound 6e exhibited the best potency for MDM2 inhibition (FP-IC50 = 9.83 μM). Compound 8e demonstrated a comprehensive potency (FP-IC50 = 15.34 μM) and anti-proliferative activity in all five of the cell lines tested (IC50 = 12.20-32.19 μM).