96522-37-1

Basic information

• Product Name: 1,2-Pyrrolidinedicarboxylic acid, 4-methoxy-, 1-(phenylmethyl) ester, (2S,4R)-
• CAS NO: 96522-37-1
• Molecular Formula: C14H17NO5
• Molecular Weight: 279.293
• Mol File: 96522-37-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1,2-Pyrrolidinedicarboxylic acid, 4-methoxy-, 1-(phenylmethyl) ester, (2S,4R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Pyrrolidinedicarboxylic acid, 4-methoxy-, 1-(phenylmethyl) ester, (2S,4R)-(96522-37-1)
• EPA Substance Registry System: 1,2-Pyrrolidinedicarboxylic acid, 4-methoxy-, 1-(phenylmethyl) ester, (2S,4R)-(96522-37-1)

Safety Data

• Hazardous Substances Data: 96522-37-1(Hazardous Substances Data)

Upstream product

• 501-53-1 benzyl chloroformate 
• 51-35-4 4R-4-hydroxyproline 
• 13504-85-3 (2S,4R)-1-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid 
• 74-88-4 methyl iodide 

Downstream Products

• 1403954-17-5 C₄₂H₄₄N₄O₈ 
• 335650-15-2 (2S,4R)-2-Hydroxymethyl-4-methoxy-pyrrolidine-1-carboxylic acid benzyl ester 

Relevant articles and documents

Stereoselective synthesis of diazabicyclic β-lactams through intramolecular amination of unactivated C(sp3)-H bonds of carboxamides by palladium catalysis

An efficient C(sp3)-H bond activation and intramolecular amination reaction via palladium catalysis at the β-position of carboxyamides to make β-lactams was described. The investigation of the substrate scope showed that the current reaction conditions favored activation of the β-methylene group. Short sequences were developed for preparation of various diazabicyclic β-lactam compounds with this method as the key step from chiral proline and piperidine derivatives.

BI-1H-BENZIMIDAZOLES AS HEPATITIS C VIRUS INHIBITORS

The present disclosure relates to compounds, compositions and methods for the treatment of Hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

Synthesis and Pharmacological Activity of Angiotensin Converting Enzyme Inhibitors: N-(Mercaptoacyl)-4-substituted-(S)-prolines

The synthesis of a series of N-(mercaptoacyl)-4-substituted-(S)-prolines (2 and 3) is described.These compounds were evaluated in vitro for inhibition of angiotensin-converting enzyme (ACE), and selected compounds were evaluated in vivo for ACE inhibition.The most potent compounds in vitro are 108, 109, 111, 114, and 116, having relative potencies of 1.0, 1.0, 1.3, 1.1, and 2.6 as compared to the potency of captopril.The most potent compounds in vivo intravenously are 108, 111, 114, 116, 117, and 97.