96530-75-5

Basic information

• Product Name: 2-HYDROXY-4-FLUOROPYRIDINE
• Synonyms: 4-FLUORO-2(1H)-PYRIDINONE;2-HYDROXY-4-FLUOROPYRIDINE;4-Fluoropyridin-2-ol;4-fluoro-2-hydroxypyridine;4-Fluoropyridin-2(1H)-one;4-fluoro-1H-pyridin-2-one;4-fluoropyridin-2-o
• CAS NO: 96530-75-5
• Molecular Formula: C₅H₄FNO
• Molecular Weight: 113.09
• Product Categories: Pyridines
• Mol File: 96530-75-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 251.7 °C at 760mmHg
• Flash Point: 106 °C
• Appearance: /
• Density: 1.26 g/cm³
• Vapor Pressure: 0.0202mmHg at 25°C
• Refractive Index: 1.508
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-HYDROXY-4-FLUOROPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXY-4-FLUOROPYRIDINE(96530-75-5)
• EPA Substance Registry System: 2-HYDROXY-4-FLUOROPYRIDINE(96530-75-5)

Safety Data

• Hazardous Substances Data: 96530-75-5(Hazardous Substances Data)

Usage

General Description

2-HYDROXY-4-FLUOROPYRIDINE is a chemical compound with the molecular formula C5H4FNO. It is a pyridine derivative with a hydroxyl group at position 2 and a fluorine atom at position 4. 2-HYDROXY-4-FLUOROPYRIDINE is commonly used in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals. It is also utilized as an intermediate in the production of various chemicals and materials. 2-HYDROXY-4-FLUOROPYRIDINE has potential applications in the fields of medicine, agriculture, and industrial chemistry due to its unique properties and reactivity. However, it is important to handle this chemical with care, as it can be hazardous if not properly managed.

InChI:InChI=1/C5H4FNO/c6-4-1-2-7-5(8)3-4/h1-3H,(H,7,8)

Upstream product

• 96530-81-3 4-fluoro-2-methoxypyridine 
• 20265-39-8 4-amino-2-methoxypyridine 
• 14395-39-2 2-methoxy-4-nitropyridine N-oxide 
• 14432-12-3 4-Amino-2-chloropyridine 
• 38767-72-5 3-deazaC 
• 34941-90-7 2,4-difluoropyridine 
• 141-52-6 sodium ethanolate 

Downstream Products

• 1263184-56-0 C₁₇H₁₇FN₂O₂ 
• 1263184-41-3 C₁₈H₁₉FN₂O₂ 

Relevant articles and documents

One-step hydroxylation of aryl and heteroaryl fluorides using mechanochemistry

Simple use of KOH allows the direct F to OH exchange of aromatic and heteroaromatic substrates under mechanochemical conditions. The reaction is performed in the absence of solvent with potassium hydroxide as OH source. As a result, this approach is both more atom economical and environmentally friendly than previously described methods for this transformation.

Lactam enolate-pyridone addition: Synthesis of 4-halocytisines

The application of a lactam enolate-pyridone addition sequence, originally developed for cytisine, has been applied successfully to generate the first examples of 4-halocytisines. Variation of the lactam component provides cyfusine and 4-fluorocyfusine.

Fluorinated heterocyclic compounds. 4-fluoro-2-pyridone

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