966-65-4

Basic information

• Product Name: 1H-Pyrazole, 4,5-dihydro-1,5-diphenyl-3-(trifluoromethyl)-
• CAS NO: 966-65-4
• Molecular Formula: C16H13F3N2
• Molecular Weight: 290.288
• Mol File: 966-65-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1H-Pyrazole, 4,5-dihydro-1,5-diphenyl-3-(trifluoromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole, 4,5-dihydro-1,5-diphenyl-3-(trifluoromethyl)-(966-65-4)
• EPA Substance Registry System: 1H-Pyrazole, 4,5-dihydro-1,5-diphenyl-3-(trifluoromethyl)-(966-65-4)

Safety Data

• Hazardous Substances Data: 966-65-4(Hazardous Substances Data)

Usage

Structure

Pyrazole derivative with a trifluoromethyl group attached to the third position of the pyrazole ring

Usage

Intermediate in the synthesis of pharmaceuticals and agrochemicals

Biological activities

Anti-inflammatory and analgesic properties

Interest to researchers

Medicinal chemistry and drug discovery fields due to unique structure and potential pharmacological applications.

Upstream product

• 100-42-5 styrene 
• 86508-64-7 3-phenyl-5-trifluoromethyl-2,2,2-tris(4-methylphenoxy)-2,3-dihydro-1,3,4,2-oxadiazaphosphole 
• 81963-44-2 bromure de N-phenyl trifluoroacetohydrazonoyle 
• 3108-32-5 (E)-1,1,1-trifluoro-4-phenyl-3-buten-2-one 
• 100-63-0 phenylhydrazine 
• 81963-42-0 phenylhydrazone of trifluoroacetaldehyde 
• 86508-62-5 2,2,2-Trichloro-3-phenyl-5-trifluoromethyl-1,3,4,2λ⁵-oxadiazaphospholine 
• 34064-31-8 2,2,2-trifluoro-N′-phenylacetohydrazide 

Downstream Products

• 2730-02-1 1,5-diphenyl-3-(trifluoromethyl)-1H-pyrazole 

Relevant articles and documents

Synthesis of Trifluoromethyl Pyrazoline and Pyrazolidine Derivatives

Reactions of α,β-unsaturated ketones containing a trifluoromethyl group with hydrazine and alkyl-, aryl-, and dialkylhydrazines yield trifluoromethyl-substituted pyrazolidines and pyrazolines.Steric strains in the pyrazolidines facilitate their dehydratio

SYNTHESIS OF 2,2,2-TRISUBSTITUTED 5-TRIFLUOROMETHYL-Δ4-1,3,4,2-OXADIAZAPHOSPHOLINES AND THEIR POTENTIALITY AS PRECURSORS OF TRIFLUOROACETONITRILE IMINES

N'-Phenyl- and methyltrifluoroacetohydrazides react with phosphorus pentachloride to give the corresponding 2,2,2-trichloro-3-phenyl- and methyl-Δ4-1,3,4,2-oxadiazaphospholines, from which various 2,2,2-trisubstituted derivatives are further synthesized.Heating 3-phenyl-2,2,2-tris(p-tolyloxy) analog with an excess of styrene affords 1,5-diphenyl-3-trifluoromethyl-2-pyrazoline, which indicates that the phospholine behaves as a precursor of trifluoroacetonitrile phenylimine.