96719-88-9

Basic information

• Product Name: 1-(β-phenethyl)-2-phenyl-1,2,3,4-tetrahydroisoquinoline
• Synonyms: 1-(β-phenethyl)-2-phenyl-1,2,3,4-tetrahydroisoquinoline
• CAS NO: 96719-88-9
• Molecular Weight: 313.442
• Mol File: 96719-88-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-(β-phenethyl)-2-phenyl-1,2,3,4-tetrahydroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(β-phenethyl)-2-phenyl-1,2,3,4-tetrahydroisoquinoline(96719-88-9)
• EPA Substance Registry System: 1-(β-phenethyl)-2-phenyl-1,2,3,4-tetrahydroisoquinoline(96719-88-9)

Safety Data

• Hazardous Substances Data: 96719-88-9(Hazardous Substances Data)

Upstream product

• 96719-83-4 1-Phenethyl-2-phenyl-3,4-dihydro-isoquinolinium; iodide 
• 3340-78-1 2-phenyl-1,2,3,4-tetrahydroisoquinoline 
• 3070-40-4 β-phenylpropionyl peroxide 
• 108-86-1 bromobenzene 
• 91-21-4 1,2,3,4-tetrahydroisoquinoline 
• 501-52-0 3-Phenylpropionic acid 
• 103-63-9 1-phenyl-2-bromoethane 
• 103-80-0 phenylacetyl chloride 
• 96719-98-1 N-Phenethyl-3,N-diphenyl-propionamide 
• 1739-00-0 (N-phenyl)phenylethylamine 
• 621-06-7 2,N-diphenylacetamide 
• 103-82-2 phenylacetic acid 
• 100-42-5 styrene 

Relevant articles and documents

Compound containing carbon-silicon bond and application thereof

The invention discloses a compound containing a carbon-silicon bond and application of the compound in construction of the carbon-carbon bond. The invention provides an application of a compound containing the carbon-silicon bond as shown in a formula I or a formula I' in a chemical reaction for constructing the carbon-carbon bond, wherein one carbon in the carbon-carbon bond is from carbon connected with silicon in the compound containing the carbon-silicon bond. According to the preparation method, the compound containing the carbon-silicon bond is used for providing a carbon free radical, and the carbon free radical can directly react with carbon provided in another molecule under a mild condition to construct the carbon-carbon bond; the preparation method is wider in substrate application range, is suitable for functional group activated C and carbon free radical substrates, and is also suitable for unactivated C-H bond substrates.

Potassium Alkylpentafluorosilicates, Primary Alkyl Radical Precursors in the C-1 Alkylation of Tetrahydroisoquinolines

In this study, we demonstrate that potassium alkylpentafluorosilicates (RSiF5K2) are efficient primary alkyl radical precursors for selective C(sp3)-C(sp3) bond-forming reactions. RSiF5K2 reagents are white, free-flowing solids and are moisture and air stable. This class of reagents enables the direct C-1 alkylation of tetrahydroisoquinolines under mild conditions via single-electron transfer. The broad substrate scope of both alkylpentafluorosilicates and tetrahydroisoquinolines is tolerated in this transformation. Both radical scavenger and EPR capture experiments show that the primary radical is generated by the oxidation of RSiF5K2. A mechanism involving alkyl radical addition to an iminium salt followed by reduction by an amine is proposed.

Antiimplantation Agents: Part II - 1,2-Diaryl-1,2,3,4-tetrahydroisoquinolines

1,2-Diaryl-3,4-dihydroisoquinolinium derivatives (5) have been synthesised from N-aryl-N-aroyl-β-phenethylamines (4) and found to exhibit no antiimplantation activity in the rat whereas many of the corresponding tetrahydroisoquinolines (6) are active.Structure-activity relationships have also been studied. 1-(p-Fluorophenyl)-6-methoxy-2-phenyl-1,2,3,4-tetrahydroisoquinoline (6u) and its nor derivative (6v) are very potent, while the ortho (6g) and the meta (6n) fluoro analogues as well as the des-fluoro derivative (6d) are quite active.Extensive biological tests have been carried out on 6g.The enantiomers (+)-6p*HCl and (-)-6q*HCl of 6n have similar activity profiles as that of 6n showing no separation of antiimplantation and estrogenic properties.Diastereomeric 2-(2-methyl-2-phenethyl)-1-phenyl-1,2,3,4-tetrahydroisoquinolines (13a and 13b) show similar properties, while the tetracyclic derivative 19 is inactive. 2-Phenoxyethyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline (26) shows moderate activity, but 1-(β-phenethyl)-2-phenyl-1,2,3,4-tetrahydroisoquinoline 29 is inactive.