96730-35-7

Basic information

• Product Name: 1-(4'-chlorophenyl)-2-phenyl-4,6-diamino-1,2-dihydro-1,3,5-triazine hydrochloride
• Synonyms: 1-(4'-chlorophenyl)-2-phenyl-4,6-diamino-1,2-dihydro-1,3,5-triazine hydrochloride
• CAS NO: 96730-35-7
• Molecular Weight: 336.224
• Mol File: 96730-35-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1-(4'-chlorophenyl)-2-phenyl-4,6-diamino-1,2-dihydro-1,3,5-triazine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4'-chlorophenyl)-2-phenyl-4,6-diamino-1,2-dihydro-1,3,5-triazine hydrochloride(96730-35-7)
• EPA Substance Registry System: 1-(4'-chlorophenyl)-2-phenyl-4,6-diamino-1,2-dihydro-1,3,5-triazine hydrochloride(96730-35-7)

Safety Data

• Hazardous Substances Data: 96730-35-7(Hazardous Substances Data)

Upstream product

• 127099-85-8 dicyandiamide 
• 100-52-7 benzaldehyde 
• 106-47-8 4-chloro-aniline 
• 4022-81-5 1-(4-chlorophenyl)biguanide hydrochloride 
• 127099-85-8 N-Cyanoguanidine 
• 20265-96-7 p-chloroaniline hydrochloride 

Downstream Products

• 41283-00-5 N²-(4-chlorophenyl)-6-phenyl-1,3,5-triazine-2,4-diamine 

Relevant articles and documents

New one-pot synthesis of 1,3,5-triazines: three-component condensation, dimroth rearrangement, and dehydrogenative aromatization

A new, effective one-pot synthesis of the 6,N2-diaryl-1,3,5-triazine-2,4-diamines under microwave irradiation was developed. The method involved an initial three-component condensation of cyanoguanidine, aromatic aldehydes, and arylamines in the presence of hydrochloric acid. Without isolation, the resulting 1,6-diaryl-1,6-dihydro-1,3,5-triazine-2,4-diamines were treated with a base to initiate Dimroth rearrangement and spontaneous dehydrogenative aromatization, affording the desired compounds. The developed method was found to be sufficiently general in scope, tolerating various aromatic aldehydes and amines; by using their combinations in the first step, a representative library of 110 compounds was successfully prepared and screened for anticancer properties.

1-Aryl-4,6-diamino-1,2-dihydrotriazine as antimalarial agent: A new synthetic route

Some novel derivatives of 1-aryl-4,6-diamino-1,2-dihydrotriazines have been synthesized using neat technology under microwaves. These were tested in vitro against both sensitive and resistant Plasmodium falciparum strains for antimalarial activity.

An efficient synthesis of 1-aryl-4,6-diamino-1,2-dihydro-1,3,5-triazines

1-Aryl-4,6-diamino-1,2-dihydro-1,3,5-triazines bearing diverse substituents at C2 and on the aromatic ring have been synthesized in good yield from an acid-catalyzed reaction between corresponding arylbiguanide and carbonyl compound in the presence of triethyl orthoacetate as a water scavenger.