96736-12-8

Basic information

• Product Name: D-ARG-PRO-LYS-PRO-D-PHE-GLN-D-TRP-PHE-D-TRP-LEU-LEU-NH2
• Synonyms: [D-ARG1, D-PHE5, D-TRP7,9, LEU11]-SUBSTANCE P;D-ARG-PRO-LYS-PRO-D-PHE-GLN-D-TRP-PHE-D-TRP-LEU-LEU-NH2;H-D-ARG-PRO-LYS-PRO-D-PHE-GLN-D-TRP-PHE-D-TRP-LEU-LEU-NH2;substance P, Phe(5)-Trp(7,9)-Leu(11)-;Substance P, [D-Arg1, D-Phe5, D-Trp7,9, Leu11];AntagonistD, D-Arg-Pro-Lys-Pro-D-Phe-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2;M.W. 1516.85 C79H109N19O12;D-Arg-L-Pro-L-Lys-L-Pro-D-Phe-L-Gln-D-Trp-L-Phe-D-Trp-L-Leu-L-Leu-NH2
• CAS NO: 96736-12-8
• Molecular Formula: C79H109N19O12
• Molecular Weight: 1516.83
• Product Categories: Ghrelin receptor
• Mol File: 96736-12-8.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: −20°C
• CAS DataBase Reference: D-ARG-PRO-LYS-PRO-D-PHE-GLN-D-TRP-PHE-D-TRP-LEU-LEU-NH2(CAS DataBase Reference)
• NIST Chemistry Reference: D-ARG-PRO-LYS-PRO-D-PHE-GLN-D-TRP-PHE-D-TRP-LEU-LEU-NH2(96736-12-8)
• EPA Substance Registry System: D-ARG-PRO-LYS-PRO-D-PHE-GLN-D-TRP-PHE-D-TRP-LEU-LEU-NH2(96736-12-8)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 96736-12-8(Hazardous Substances Data)

Usage

Description

D-ARG-PRO-LYS-PRO-D-PHE-GLN-D-TRP-PHE-D-TRP-LEU-LEU-NH2, also known as [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P, is a synthetic peptide derived from the naturally occurring neuropeptide Substance P. It functions as a broad-spectrum neuropeptide antagonist and inverse agonist, exhibiting the ability to block the activity of several neuropeptide receptors.

Uses

Used in Pharmaceutical Industry:
[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P is used as a broad-spectrum neuropeptide antagonist and inverse agonist for the development of therapeutic agents targeting various neurological and inflammatory disorders. Its ability to block multiple neuropeptide receptors makes it a promising candidate for the treatment of conditions such as pain, migraine, and inflammatory bowel disease.
Used in Research Applications:
In addition to its potential therapeutic applications, [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P is also used as a research tool to study the function and regulation of neuropeptide receptors. Its broad antagonistic activity allows researchers to investigate the role of these receptors in various physiological and pathological processes, contributing to a better understanding of their mechanisms of action and potential as therapeutic targets.