96938-54-4Relevant articles and documents
Dual Roles of N,N-Dimethylformamide in Benzothiazoles Synthesis from N-Benzoyl-N′-(2,4,6-trichlorophenyl)thiourea
Li, Qianjin,Wang, Dan,Chen, Min,Ling, Baoping,Kujawski, Piotr,Yang, Chunlong,Cao, Qianyong,Wang, Fenying
, p. 287 - 294 (2019/07/05)
Abstract: N,N-Dimethylformamide (DMF) is not only a common polar solvent in chemistry, but also a reaction reagent, a catalyst and a stabilizer. In this paper, a new reaction was found accidently where DMF acted as both solvent and catalyst. By dissolving
New ferrocenyl guanidines as potent antioxidants, protein kinase inhibitors and cytotoxic agents against human leukemia THP-1 cell line
Gul,Badshah,Altaf, A. Ali,Tabassum,Zia
, p. 2684 - 2689 (2017/12/26)
Six new ferrocenyl guanidines were synthesized and characterized by elemental analysis, FT-IR and 1H and 13C NMR. Compounds 1–6 were screened for antioxidant, protein kinase inhibition, lethality of brine shrimp, and cytotoxicity aga
Solution-phase microwave assisted parallel synthesis of N,N′-disubstituted thioureas derived from benzoic acid: Biological evaluation and molecular docking studies
Rauf, Muhammad Khawar,Talib, Ammara,Badshah, Amin,Zaib, Sumera,Shoaib, Khurram,Shahid, Mohammad,Fl?rke, Ulrich,Imtiaz-Ud-Din,Iqbal, Jamshed
, p. 487 - 496 (2013/11/19)
An efficient and facile microwave-assisted solution phase parallel synthesis for a 26-member library of N,N′-disubstituted thiourea analogs were accomplished successfully. The reaction time for synthesis of analogs was drastically reduced from a reported 8-12 h to only 10 min. Compounds were more than 95% pure, as characterized by modern analytical techniques, i.e. 1H & 13C NMR and FT-IR. The solid phase structural analysis has also been performed by single crystal XRD analysis. Synthesized compounds were preliminary screened for their in vitro urease inhibition and antifungal activity. Most of the compounds were found to be potent inhibitors of urease. However, the most significant activity was found for 11 with IC 50 of 1.67 μM. The docking scores correlate with the IC 50 values of inhibitors.