97-15-4

Basic information

• Product Name: Benzenesulfonamide, 4-methyl-N-(2-methyl-4-nitrophenyl)-
• CAS NO: 97-15-4
• Molecular Formula: C14H14N2O4S
• Molecular Weight: 306.342
• Mol File: 97-15-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzenesulfonamide, 4-methyl-N-(2-methyl-4-nitrophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide, 4-methyl-N-(2-methyl-4-nitrophenyl)-(97-15-4)
• EPA Substance Registry System: Benzenesulfonamide, 4-methyl-N-(2-methyl-4-nitrophenyl)-(97-15-4)

Safety Data

• Hazardous Substances Data: 97-15-4(Hazardous Substances Data)

Upstream product

• 95-53-4 o-toluidine 
• 98-59-9 p-toluenesulfonyl chloride 
• 99-52-5 2-methyl-4-nitro-benzenamine 
• 80-28-4 N-(2-methylphenyl)-p-toluenesulphonamide 

Downstream Products

• 899438-81-4 toluene-4-sulfonic acid-(4-amino-2,N-dimethyl-anilide) 
• 99-52-5 2-methyl-4-nitro-benzenamine 
• 304912-09-2 toluene-4-sulfonic acid-(2,N-dimethyl-4-nitro-anilide) 
• 35481-04-0 toluene-4-sulfonic acid-(4-amino-2-methyl-anilide) 

Relevant articles and documents

Quinoline derivative as well as preparation method and purpose thereof

The invention provides a quinoline derivative and a composition containing the derivative. The invention also provides a method for preparing the derivative and a purpose of the derivative for preventing or treating harmful pathogenic bacteria and killing

Design, synthesis and biological evaluation of sulfonamide-substituted diphenylpyrimidine derivatives (Sul-DPPYs) as potent focal adhesion kinase (FAK) inhibitors with antitumor activity

A class of sulfonamide-substituted diphenylpyrimidines (Sul-DPPYs) were synthesized to improve activity against the focal adhesion kinase (FAK). Most of these new Sul-DPPYs displayed moderate activity against the FAK enzyme with IC50 values of less than 100?nM; regardless, they could effectively inhibit several classes of refractory cancer cell lines with IC50 values of less than 10?μM, including the pancreatic cancer cell lines (AsPC-1, Panc-1 and BxPC-3), the NSCLC-resistant H1975 cell line, and the B lymphocyte cell line (Ramos cells). Results of flow cytometry indicated that inhibitor 7e promoted apoptosis of pancreatic cancer cells in a dose-dependent manner. In addition, it almost completely induced the apoptosis at a concentration of 10?μM. Compound 7e may be selected as a potent FAK inhibitor for the treatment of pancreatic cancer.

REACTION OF N-ARYLSULFONAMIDES WITH NITROSATING AGENTS

Only the mononitro derivatives are formed by the action of nitrosating agents on N-arylsulfonamides containing halogen atom and alkoxy and alkyl groups in the amide ring.The nature of the effect and the directing action of the substituents are discussed a