970-48-9

Basic information

• Product Name: 4',7-DIMETHOXY-6-HYDROXYISOFLAVONE
• Synonyms: TEXASIN 7-METHYL ETHER;4',7-DIMETHOXY-6-HYDROXYISOFLAVONE;ALFALONE;4H-1-Benzopyran-4-one, 6-hydroxy-7-methoxy-3-(4-methoxyphenyl)-;Isoflavone, 6-hydroxy-4',7-dimethoxy-;6-Hydroxy-7,4'-dimethoxyisoflavone;6-Hydroxy-7-methoxy-3-(4-methoxyphenyl)-4H-1-benzopyran-4-one;Alfalone (isoflavone)
• CAS NO: 970-48-9
• Molecular Formula: C₁₇H₁₄O₅
• Molecular Weight: 298.29
• Product Categories: Miscellaneous Natural Products;Iso-Flavones
• Mol File: 970-48-9.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4',7-DIMETHOXY-6-HYDROXYISOFLAVONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4',7-DIMETHOXY-6-HYDROXYISOFLAVONE(970-48-9)
• EPA Substance Registry System: 4',7-DIMETHOXY-6-HYDROXYISOFLAVONE(970-48-9)

Safety Data

• Hazardous Substances Data: 970-48-9(Hazardous Substances Data)

Upstream product

• 897-46-1 6,7-dihydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one 
• 17817-31-1 6,7,4'-trihydroxyisoflavone 
• 79744-55-1 1-(2,5-dihydroxy-4-methoxyphenyl)-2-(4'-methoxyphenyl)ethanone 
• 122-51-0 orthoformic acid triethyl ester 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 97148-46-4 6-hydroxy-4',7-dimethoxyisoflavane 

Relevant articles and documents

Free-radical-scavenging, antityrosinase, and cellular melanogenesis inhibitory activities of synthetic isoflavones

In this study, we examined the potential of synthetic isoflavones for application in cosmeceuticals. Twenty-five isoflavones were synthesized and their capacities of free-radical-scavenging and mushroom tyrosinase inhibition, as well as their impact on cell viability of B16F10 murine melanoma cells and HaCaT human keratinocytes were evaluated. Isoflavones that showed significant mushroom tyrosinase inhibitory activities were further studied on reduction of cellular melanin formation and antityrosinase activities in B16F10 melanocytes in vitro. Among the isoflavones tested, 6-hydroxydaidzein (2) was the strongest scavenger of both ABTS.+ and DPPH. radicals with SC50 values of 11.3±0.3 and 9.4±0.1 μM, respectively. Texasin (20) exhibited the most potent inhibition of mushroom tyrosinase (IC50 14.9±4.5 μM), whereas retusin (17) showed the most efficient inhibition both of cellular melanin formation and antityrosinase activity in B16F10 melanocytes, respectively. In summary, both retusin (17) and texasin (20) exhibited potent free-radical-scavenging capacities as well as efficient inhibition of cellular melanogenesis, suggesting that they are valuable hit compounds with potential for advanced cosmeceutical development.

Synthesis of isoflavones via base catalysed condensation reaction of deoxybenzoin

Base catalysed condensation reaction of o-hydroxyl-α- phenylacetophenones with formyl reagents affords various substituted isoflavones. Many bases were tested in the condensation reaction and DMAP was found to be the most effective catalysis.