97024-95-8Relevant articles and documents
Highly diastereoselective alkylation of vicinal dianions of chiral succinic acid derivatives: A new general strategy to (R)-β-arylmethyl-γ- butyrolactones
Pohmakotr, Manat,Soorukram, Darunee,Tuchinda, Patoomratana,Prabpai, Samran,Kongsaeree, Palangpon,Reutrakul, Vichai
, p. 4315 - 4318 (2007/10/03)
The vicinal dianions derived from chiral succinic acid derivatives, 1,4-bis[(4R,5S)-3,4-dimethyl-2-oxo-5-phenylimidazolidin-1-yl]butane-1,4-dione and 1,4-bis[(4S,5R)-3,4-dimethyl-2-oxo-5-phenylimidazolidin-1-yl]butane-1,4- dione react with arylmethyl bromides with high diastereo- and regio-selectivity to provide the corresponding chiral α-arylmethylated succinic acid derivatives; the (R)-products are converted into (R)-β-arylmethyl-γ- butyrolactones and (R)-α-arylmethyl-γ-butyrolactones.
Asymmetric Synthesis of (R)- and (S)-4-(Substituted Benzyl)dihydrofuran-2(3H)-ones: An Application of the Ruthenium-binap Complex-catalysed Asymmetric Hydrogenation of Alkylidenesuccinic Acids
Shao, Liming,Miyata, Shiro,Muramatsu, Hitoshi,Kawano, Hiroyuki,Ishii, Youichi,et al.
, p. 1441 - 1445 (2007/10/02)
A concise synthesis of (S)- or (R)-4-(substituted benzyl)dihydrofuran-2(3H)-ones (1) with high enantiomeric purity is presented. (S)- or (R)-(Substituted benzyl)succinic acids (6) 97percent enantiomeric excess) were first prepared by Ru2Cl4(R)- or (S