97025-36-0

Basic information

• Product Name: 1,2-Benzenedicarboxylic acid, 4-methoxy-, diethyl ester
• CAS NO: 97025-36-0
• Molecular Formula: C13H16O5
• Molecular Weight: 252.267
• Mol File: 97025-36-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,2-Benzenedicarboxylic acid, 4-methoxy-, diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Benzenedicarboxylic acid, 4-methoxy-, diethyl ester(97025-36-0)
• EPA Substance Registry System: 1,2-Benzenedicarboxylic acid, 4-methoxy-, diethyl ester(97025-36-0)

Safety Data

• Hazardous Substances Data: 97025-36-0(Hazardous Substances Data)

Usage

Chemical structure

Ester of phthalic acid

Applications

Plasticizer in flexible polyvinyl chloride (PVC) products
Production of coatings, adhesives, and synthetic leather

Additional uses

Solvent
Fragrance ingredient in perfumes and personal care products

Environmental concerns

Potential environmental pollutant

Health concerns

Subject to regulation due to potential impact on human health

Regulatory status

Under scrutiny and regulation in some regions due to environmental and health concerns

Upstream product

• 62415-74-1 3,4-dibromoanisole 
• 541-41-3 chloroformic acid ethyl ester 
• 5368-81-0 methyl 3-methoxybenzoate 

Relevant articles and documents

Synthesis of 1,2-dimetallic compounds via direct insertion of zinc powder in the presence of InCl3: Synthesis of ortho-bis-functionalized aromatics

A variety of functionalized 1,2-dizinc reagents can be prepared by an indium-catalyzed insertion of zinc powder into aromatic 1,2-dibromides or 1-bromo-2-triflates. These 1,2-dimetallics undergo Cu- or Pd-catalyzed acylations, allylations, or cross couplings. Georg Thieme Verlag KG Stuttgart · New York.

Pyrophtalones VII. Synthese et activite anti-inflammatoire de (pyridinyl-4)-2 indanediones-1,3 substituees sur le noyau benzenique et/ou sur l'heterocycle

Pyrophthalones VII.Synthesis and anti-inflammatory activity of 2-(4-pyridinyl)indane-1,3-diones diversely substituted on the benzene ring.Access routes to 2-(1,4-dihydro 4-pyridinylidene) indane-1,3-diones diversely substituted on the benzene ring are studied.The regiospecific attack of these β diketoenamines by alkyl iodides leads to N-substituted compounds.These derivatives may be obtained by any of three possible methods: (1) condensation of 4-methyl pyridine with ethyl phthalates in the absence of catalyst; (2) oxidative condensation of N-alkyl-pyridinium bromides with indane-1,3-diones; (3) aminolysis of 2-(4-4H-pyranylidene) indane-1,3-diones.Pharmacomodulation by the introduction of oxygen or sulfur containing functions (ether, thioether, alcohol, ketone, acid, ester, amide) on the nitrogen of the basic molecule is not very fruitful; only the acetic derivative 19 manifests marked antiinflammatory activity unaccompanied by anti-coagulant action.The presence of chloro, nitro or methoxyl groups on 5 after N-substitution by ethyl or piperidinylethyl groups appears to be more favorable.The most active compound 57 decreases prostaglandin production and leukocyte migration without affecting either cyclooxygenase or 5-lipoxygenase.Its interference, direct or indirect, with phospholipasic A2 activity may be envisaged in particular.Keywords - 2-(4-pyridinyl)indane-1,3-diones / heterocyclic β diketoenamines / partition coefficient / anti-inflammatory activity / mechanism of action