97031-68-0Relevant articles and documents
Efficient synthesis of 3,5-dicarbamoyl-1,4-dihydropyridines from pyridinium salts: Key molecules in understanding NAD(P)+/NAD(P)H pathways
Mellini, Paolo,De Vita, Daniela,Di Rienzo, Barbara,La Rosa, Salvatore,Padova, Alessandro,Scipione, Luigi,Tortorella, Silvano,Friggeri, Laura
, p. 221 - 226 (2015)
3,5-Dicarbamoyl-1,4-dihydropyridines were prepared in high yields using a green protocol by reduction of the corresponding pyridinium salts in aqueous buffered sodium dithionite solutions. The pH value is a fundamental parameter for the reduction step and depends on the nature of substituent groups at positions 1, 3, and 5 of the pyridinium salts. These 3,5-dicarbamoyl dihydropyridines show a lower tendency towards oxidation and a higher stability than N-benzyl-3-carbamoyl-1,4-dihydropyridine at low pH values.