97181-50-5

Basic information

• Product Name: N-(1-benzyl-4-piperidinyl)-2,2,2-trifluoroacetamide
• Synonyms: N-(1-benzyl-4-piperidinyl)-2,2,2-trifluoroacetamide
• CAS NO: 97181-50-5
• Molecular Weight: 286.297
• Mol File: 97181-50-5.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: N-(1-benzyl-4-piperidinyl)-2,2,2-trifluoroacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(1-benzyl-4-piperidinyl)-2,2,2-trifluoroacetamide(97181-50-5)
• EPA Substance Registry System: N-(1-benzyl-4-piperidinyl)-2,2,2-trifluoroacetamide(97181-50-5)

Safety Data

• Hazardous Substances Data: 97181-50-5(Hazardous Substances Data)

Upstream product

• 50541-93-0 4-amino-1-benzylpiperidine 
• 407-25-0 trifluoroacetic anhydride 

Downstream Products

• 478832-19-8 N-(1-benzyl-4-piperidinyl)-2,2,2-trifluoro-N-methylacetamide 
• 153198-08-4 5-bromo-2,3-dimethoxy-N-(piperidin-4-yl)benzamide 
• 153198-07-3 5-bromo-2,3-dimethoxy-N-<1-(tert-butyloxycarbonyl)piperidin-4-yl>benzamide 
• 886508-40-3 1-cycloheptyl-piperidin-4-ylamine 
• 59528-79-9 4-amino-1-cyclohexyl-piperidine 
• 132740-50-2 1-cyclopentyl-4-piperidinylamine 
• 1026305-97-4 4-[2-(2-fluoro-phenyl)-acetylamino]-piperidine-1-carboxylic acid tert-butyl ester 
• 1027138-18-6 4-[2-(3-bromo-phenyl)-acetylamino]-piperidine-1-carboxylic acid tert-butyl ester 
• 1026356-34-2 4-[2-(3-fluoro-phenyl)-acetylamino]-piperidine-1-carboxylic acid tert-butyl ester 
• 1016711-29-7 2-(3-fluoro-phenyl)-N-piperidin-4-yl-acetamide 

Relevant articles and documents

Synthesis and structure-activity relationships of naphthamides as dopamine D3 receptor ligands

A series of naphthamides were synthesized, and the affinities of these compounds were determined for dopamine D2 and D3 receptors using radioligand binding techniques. The naphthamide compounds that were prepared include N-(1- alkylp

Synthesis and gastrointestinal prokinetic activity of novel benzamide derivatives with amphoteric side chains

Novel benzamide derivatives (19-24, 32a-c, 43d-f), each possessing a cycloaminoalkanecarboxylic acid side chain, were synthesized and their gastrointestinal prokinetic and dopamine D2 receptor antagonist activities were evaluated. 4-[(4-Amino-5

18F-labeled benzamides for studying the dopamine D2 receptor with positron emission tomography

Two series of (N-benzylpiperidin-4-yl)- and (9-azabicyclo[3.3.1]nonan- 3β-yl)benzamides were prepared, and in vitro binding assays were used to measure the affinity of these compounds for dopamine D2, dopamine D3, serotonin 5-HT2, and α2-adrenergic receptors. The results of these studies indicated compounds 23, 26b, and 34 have the selectivity needed for in vivo studies of the D2 (and possibly D3) receptors. 18F-Labeled analogues of 23, 26b and 34 were prepared by N-alkylation of the corresponding desbenzyl precursors with [18F]-4-fluorobenzyl iodide. Preliminary in vivo studies demonstrated that [18F]-23 and [18F]-26b are suitable candidates for further evaluation in positron emission tomography imaging studies. The slow rate of washout of [18F]-34 from nondopaminergic regions and its comparatively high lipophilicity indicates that this compound may not be suitable for imaging studies because of a high level of nonspecific binding.