972-50-9

Basic information

• Product Name: (7alpha,17beta)-7,17-dihydroxy-17-methylandrost-4-en-3-one
• Synonyms: 7alpha,17beta-Dihydroxy-17alpha-methylandrost-4-en-3-one; 7alpha-Hydroxy-17alpha-methyltestosterone
• CAS NO: 972-50-9
• Molecular Formula: C₂₀H₃₀O₃
• Molecular Weight: 318.4504
• Mol File: 972-50-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 477.2°C at 760 mmHg
• Flash Point: 256.5°C
• Density: 1.17g/cm³
• Vapor Pressure: 4.14E-11mmHg at 25°C
• Refractive Index: 1.573
• CAS DataBase Reference: (7alpha,17beta)-7,17-dihydroxy-17-methylandrost-4-en-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: (7alpha,17beta)-7,17-dihydroxy-17-methylandrost-4-en-3-one(972-50-9)
• EPA Substance Registry System: (7alpha,17beta)-7,17-dihydroxy-17-methylandrost-4-en-3-one(972-50-9)

Safety Data

• Hazardous Substances Data: 972-50-9(Hazardous Substances Data)

Usage

General Description

The chemical compound "(7alpha,17beta)-7,17-dihydroxy-17-methylandrost-4-en-3-one" is a steroid derivative with a molecular structure consisting of a 17-methylated androstenedione. It is a hormone that is produced naturally in the body and plays a role in the regulation of various physiological processes. (7alpha,17beta)-7,17-dihydroxy-17-methylandrost-4-en-3-one is also used as an intermediate in the synthesis of steroid hormones and has been studied for its potential pharmaceutical applications. The 7alpha,17beta configuration indicates the stereochemistry of the compound, and the presence of hydroxyl groups at the 7 and 17 positions indicates its potential for metabolic transformation and hormonal activity.

Upstream product

• 58-18-4 17-methyltestosterone 

Relevant articles and documents

Application of α- and β-naphthoflavones as monooxygenase inhibitors of Absidia coerulea KCh 93, Syncephalastrum racemosum KCh 105 and Chaetomium sp. KCh 6651 in transformation of 17α-methyltestosterone

In this work, 17α-methyltestosterone was effectively hydroxylated by Absidia coerulea KCh 93, Syncephalastrum racemosum KCh 105 and Chaetomium sp. KCh 6651. A. coerulea KCh 93 afforded 6β-, 12β-, 7α-, 11α-, 15α-hydroxy derivatives with 44%, 29%, 6%, 5% and 9% yields, respectively. S. racemosum KCh 105 afforded 7α-, 15α- and 11α-hydroxy derivatives with yields of 45%, 19% and 17%, respectively. Chaetomium sp. KCh 6651 afforded 15α-, 11α-, 7α-, 6β-, 9α-, 14α-hydroxy and 6β,14α-dihydroxy derivatives with yields of 31%, 20%, 16%, 7%, 5%, 7% and 4%, respectively. 14α-Hydroxy and 6β,14α-dihydroxy derivatives were determined as new compounds. Effect of various sources of nitrogen and carbon in the media on biotransformations were tested, however did not affect the degree of substrate conversion or the composition of the products formed. The addition of α- or β-naphthoflavones inhibited 17α-methyltestosterone hydroxylation but did not change the percentage composition of the resulting products.