97209-18-2Relevant articles and documents
Pyrrolizidine Alkaloid Biosynthesis. Synthesis of 14C-Labelled Homospermidines and their Incorporation into Retronecine
Khan, Hassan A.,Robins, David J.
, p. 819 - 824 (2007/10/02)
14C>Homospermidine (12) was synthesized and fed to Senecio isatideus plants.The 14C radioactivity was located predominantly in the base portion of the alkaloid.Degradation of the retronecine showed that 43-44percent of the radioactivity was at C-9 and 2-4percent was at C-(5+6+7).In a complementary experiment, 14C>homospermidine (15) was prepared and fed to S. isatideus plants.The 14C radioactivity was again located mainly in retronecine (2).Degradation of retronecine demonstrated that 1-4percent of the radioactivity was at C-9 and 45-47percent was at C-(5+6+7).Homospermidine is therefore incorporated without significant breakdown into retronecine.Homospermidine was also shown to be present in S. isatideus plants by an intermediate trapping experiment.