97341-51-0

Basic information

• Product Name: Ethyl 2,4-dihydroxy-7-phenylpyrido[2,3-d]pyrimidine-5-carboxylate
• Synonyms: Ethyl 2,4-dihydroxy-7-phenylpyrido[2,3-d]pyrimidine-5-carboxylate
• CAS NO: 97341-51-0
• Molecular Weight: 311.297
• Mol File: 97341-51-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Ethyl 2,4-dihydroxy-7-phenylpyrido[2,3-d]pyrimidine-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 2,4-dihydroxy-7-phenylpyrido[2,3-d]pyrimidine-5-carboxylate(97341-51-0)
• EPA Substance Registry System: Ethyl 2,4-dihydroxy-7-phenylpyrido[2,3-d]pyrimidine-5-carboxylate(97341-51-0)

Safety Data

• Hazardous Substances Data: 97341-51-0(Hazardous Substances Data)

Upstream product

• 873-83-6 4-Amino-2,6-dihydroxypyrimidine 
• 6296-54-4 ethyl 2,4-dioxo-4-phenylbutyrate 

Downstream Products

• 96983-27-6 2,4-dioxo-7-phenyl-1,2,3,4-tetrahydro-pyrido[2,3-d]pyrimidine-5-carboxylic acid 

Relevant articles and documents

Replacement of the quinoline system in 2-phenyl-4-quinolinecarboxamide NK-3 receptor antagonists

Results from a medicinal chemistry approach aimed at replacing the quinoline ring system in the potent and selective human neurokinin-3 (hNK-3) receptor antagonists 1-4 of general formula I are discussed. The data give further insight upon the potential NK-3 pharmacophore. In particular, it is highlighted that both the benzene-condensed ring and the quinoline nitrogen are crucial determinants for optimal binding affinity to the hNK-3 receptor. Some novel compounds maintained part of the binding affinity to the receptor (5, 6, 10 and 13) and compound 5, featuring the naphthalene ring system, appears to be suitable for further modifications: it offers the option to introduce electron-withdrawing groups at position 2 and 4, conferring on the ring an overall electron-deficiency similar to that of the quinoline.