97373-17-6

Basic information

• Product Name: (3beta,4alpha,8alpha,12xi)-15-(acetyloxy)-3,4-dihydroxy-12,13-epoxytrichothec-9-en-8-yl 3-hydroxy-3-methylbutanoate
• CAS NO: 97373-17-6
• Molecular Formula: C₂₂H₃₂O₉
• Molecular Weight: 440.4841
• Mol File: 97373-17-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 596.4°C at 760 mmHg
• Flash Point: 202.4°C
• Density: 1.36g/cm³
• Vapor Pressure: 1.04E-16mmHg at 25°C
• Refractive Index: 1.578
• CAS DataBase Reference: (3beta,4alpha,8alpha,12xi)-15-(acetyloxy)-3,4-dihydroxy-12,13-epoxytrichothec-9-en-8-yl 3-hydroxy-3-methylbutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (3beta,4alpha,8alpha,12xi)-15-(acetyloxy)-3,4-dihydroxy-12,13-epoxytrichothec-9-en-8-yl 3-hydroxy-3-methylbutanoate(97373-17-6)
• EPA Substance Registry System: (3beta,4alpha,8alpha,12xi)-15-(acetyloxy)-3,4-dihydroxy-12,13-epoxytrichothec-9-en-8-yl 3-hydroxy-3-methylbutanoate(97373-17-6)

Safety Data

• Hazardous Substances Data: 97373-17-6(Hazardous Substances Data)

Upstream product

• 625-08-1 3-Hydroxy-3-methylbutyric acid 
• 26934-87-2 HT-2 toxin 

Relevant articles and documents

The catalytic activity of cytochrome P450 3A22 is critical for the metabolism of T-2 toxin in porcine reservoirs

Contamination of food by T-2 toxin, a trichothecene mycotoxin, poses a serious threat to human health. We report the identification of cytochrome P450 3A22 (CYP3A22) responsible for 3′-hydroxylation of T-2 and HT-2 in pigs. The present study shows that T-2 toxin significantly induces CYP3A22 expression in primary piglet hepatocytes. Moreover, recombinant pig CYP3A22 converted T-2 toxin into TC-1 (3′-OH-T-2 toxin) and HT-2 toxin into TC-3 (3′-OH-HT-2 toxin) in vitro. These results suggest that pig CYP3A22 primarily eliminates T-2 and HT-2 toxins by 3′-hydroxylation of isovaleryl groups. Therefore, CYP3A22 is critical for xenobiotic metabolism and endogenous biochemical biotransformation of trichothecene mycotoxin in porcine reservoirs.