97472-93-0

Basic information

• Product Name: 3-(4-aminophenyl)-7-methoxy-4H-chromen-4-one
• Synonyms: 3-(4-aminophenyl)-7-methoxy-4H-chromen-4-one
• CAS NO: 97472-93-0
• Molecular Weight: 267.284
• Mol File: 97472-93-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(4-aminophenyl)-7-methoxy-4H-chromen-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-aminophenyl)-7-methoxy-4H-chromen-4-one(97472-93-0)
• EPA Substance Registry System: 3-(4-aminophenyl)-7-methoxy-4H-chromen-4-one(97472-93-0)

Safety Data

• Hazardous Substances Data: 97472-93-0(Hazardous Substances Data)

Upstream product

• 19816-54-7 7-methoxy-3-(4-nitrophenyl)-4H-1-benzopyran-4-one 
• 73220-42-5 3-iodo-7-methoxy-chromen-4-one 
• 73220-33-4 3-(dimethylamino)-1-(4-ethoxy-2-hydroxyphenyl)prop-2-en-1-one 
• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 

Downstream Products

• 486-63-5 isoformononetin 

Relevant articles and documents

Synthesis of novel isoflavone/benzo-δ-sultam hybrids as potential anti-inflammatory drugs

A small series of novel isoflavone/benzo-δ-sultam hybrids was synthesised and evaluated as potential anti-inflammatory and neuroprotective drugs in LPS-activated BV2 microglia. The benzo-δ-sultam core was constructed in a two-step reaction by coupling 2-halobenzenesulfonamide derivatives with terminal alkynes, followed by a 6-endo-dig cyclisation. The synthesised compounds, including precursors and hybrids, were tested for their ability to inhibit NO and TNF-α production in LPS-stimulated BV2 microglial cells, and the results are promising. The most potent hybrid reduces the NO production to 41%, and the TNF-α to 34% at 20 μM final concentration in the well.