97501-92-3

Basic information

• Product Name: CHYMASE
• Synonyms: chymase human
• CAS NO: 97501-92-3
• Molecular Weight: 0
• Mol File: 97501-92-3.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: −20°C
• CAS DataBase Reference: CHYMASE(CAS DataBase Reference)
• NIST Chemistry Reference: CHYMASE(97501-92-3)
• EPA Substance Registry System: CHYMASE(97501-92-3)

Safety Data

• Hazard Codes: B
• WGK Germany: 1
• Hazardous Substances Data: 97501-92-3(Hazardous Substances Data)

Usage

Description

Chymase is a type of serine protease enzyme that is primarily found in the granules of mast cells and is involved in various physiological processes, including inflammation, blood pressure regulation, and tissue remodeling. It has been the subject of research for its potential role in various diseases and conditions.

Uses

Used in Pharmaceutical Industry:
Chymase is used as a target for drug development for the treatment of various diseases, such as hypertension, heart failure, and fibrosis. Inhibitors of chymase have been shown to reduce the activity of the enzyme and its downstream effects, leading to potential therapeutic benefits.
Used in Research:
Chymase is used as a research tool to study the role of the enzyme in various biological processes and diseases. It has been used in studies to investigate the effects of certain compounds, such as Panax notoginseng flower extract, on the TGF-β/Smad signal transduction pathway in heart remodeling. Additionally, chymase has been used in studies to investigate blood glucose levels and survival in animal models of diabetes, such as streptozotocin-treated human chymase transgenic mice.
Overall, chymase is a versatile enzyme with potential applications in both the pharmaceutical industry and research settings, making it an important target for further study and development.

Biochem/physiol Actions

The enzyme rapidly converts angiotensin I to angiotensin II. Optimum pH for the enzyme activity is between 7.5 and 9.0. Enzyme activity is inhibited by soybean trypsin inhibitor, phenylmethylsulfonyl fluoride and chymostatin.