97606-27-4Relevant articles and documents
Five-member thio-heterocyclic fused naphthalimides with aminoalkyl side chains: Intercalation and photocleavage to DNA
Xu, Yufang,Qu, Baoyuan,Qian, Xuhong,Li, Yonggang
, p. 1139 - 1142 (2005)
Novel five-member thio-heterocyclic fused naphthalimides with aminoalkyl side chains were designed, synthesized and evaluated. These compounds have high Scatchard binding constants. They could damage DNA (supercoiled pBR322) from form I (closed) to II (ni
Naphthalimide intercalators with chiral amino side chains: Effects of chirality on DNA binding, photodamage and antitumor cytotoxicity
Yang, Qing,Yang, Peng,Qian, Xuhong,Tong, Lianpeng
scheme or table, p. 6210 - 6213 (2009/07/18)
Several novel heterocyclic-fused naphthalimides intercalators with chiral amino side chains were investigated. Their side chains' chiral configuration determines DNA binding activities in the order: S-enantiomers > R-enantiomers. And their DNA photodamagi
Novel naphthalimide hydroperoxide photonucleases: The role of thiocyclic-Fused area and the difference in spectra, photochemistry and photobiological activity
Xu, Yufang,Qian, Xuhong,Yao, Wei,Mao, Ping,Cui, Jingnan
, p. 5427 - 5433 (2007/10/03)
Novel five- and six-membered thiocyclic-fused naphthalimide hydroperoxides (7, 8) as photonucleases were designed, synthesized via unusual isomerization in Pschorr cyclization and photooxygenation. The five-membered 7 was able to induce single-strand nick
