97730-07-9Relevant articles and documents
Tetrahydrofuran, one of the most popular solvents in organic synthesis, is not completely inert
Makowiec,Rachon
, p. 487 - 492 (2007/10/03)
Tetrahydrofuran undergoes fast ring cleavage in the reaction with PhI(OH)OTs/(RO)2P(O)H system, which causes the formation of O-(dialkoxyphosphoryl)-O′-tosyl-1,4-butanediol. This fact indicates that tetrahydrofuran is not suitable as a solvent for reactions with strong electrophilic reagents, such as hypervalent iodine reagents.