97748-75-9

Basic information

• Product Name: 2'-Azido-2'-deoxy-5-methyluridine
• Synonyms: 2'-Azido-2'-deoxy-5-methyluridine
• CAS NO: 97748-75-9
• Molecular Formula: C₁₀H₁₃N₅O₅
• Molecular Weight: 283.24072
• Mol File: 97748-75-9.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2'-Azido-2'-deoxy-5-methyluridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-Azido-2'-deoxy-5-methyluridine(97748-75-9)
• EPA Substance Registry System: 2'-Azido-2'-deoxy-5-methyluridine(97748-75-9)

Safety Data

• Hazardous Substances Data: 97748-75-9(Hazardous Substances Data)

Usage

General Description

2'-Azido-2'-deoxy-5-methyluridine is a nucleoside compound that consists of a uridine base attached to a deoxyribose sugar with an azido group at the 2' carbon position and a methyl group at the 5' carbon position. This chemical is commonly used in the synthesis of nucleic acid analogs and as a tool in studying RNA and DNA structures and interactions. It is also used in the development of antiviral drugs and as a precursor in the synthesis of other nucleoside analogs. The azido group in 2'-Azido-2'-deoxy-5-methyluridine makes it a useful tool in click chemistry, a type of chemical reaction that is used to selectively bind molecules together, making it a valuable compound in a variety of biochemical and medicinal applications.

Upstream product

• 22423-26-3 O-2,2'-cyclo-5-methyluridine 

Relevant articles and documents

2′-Deoxy-2′-azidonucleoside analogs: synthesis and evaluation of antitumor and antimicrobial activity

Abstract: A series of ten pyrimidine nucleosides modified in 2′ position with azide or amine group was tested for the antibacterial, antifungal and cytotoxic activity. The cytotoxic effect was determined on three cancer (CCRF-CEM, MCF7, HeLa) and one norm

Synthesis and evaluation of thymidine-5′-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase

A number of 2′- and 3′-modified thymidine 5′-O-monophosphate analogues were synthesized as potential leads for new anti-mycobacterial drugs. Evaluation of their affinity for Mycobacterium tuberculosis thymidine monophosphate kinase showed that a 2′-halogeno substituent and a 3′-azido function are the most favorable leads for further development of potent inhibitors of this enzyme.