97801-48-4Relevant articles and documents
Furoxans (1,2,5-Oxadiazole- N -oxides) as novel no mimetic neuroprotective and procognitive agents
Schiefer, Isaac T.,Vandevrede, Lawren,Fa', Mauro,Arancio, Ottavio,Thatcher, Gregory R.J.
supporting information; experimental part, p. 3076 - 3087 (2012/06/01)
Furoxans (1,2,5-oxadiazole-N-oxides) are thiol-bioactivated NO-mimetics that have not hitherto been studied in the CNS. Incorporation of varied substituents adjacent to the furoxan ring system led to modulation of reactivity toward bioactivation, studied
Peptidic aldehydes based on α- and β-amino acids: Synthesis, inhibition of m-Calpain, and anti-cataract properties
Payne, Richard J.,Brown, Karina M.,Coxon, James M.,Morton, James D.,Lee, Hannah Yun-Young,Abell, Andrew D.
, p. 877 - 884 (2007/10/03)
We present a new synthesis of SJA6017 (a potent m-calpain inhibitor) and its adaptation in order to prepare analogues in which the constituent Leu and Val residues are systematically replaced with their corresponding β-amino acids and/or the N-terminal fl
Structure-activity relationship study and drug profile of N-(4-fluorophenylsulfonyl)-L-valyl-L-leucinal (SJA6017) as a potent calpain inhibitor
Inoue, Jun,Nakamura, Masayuki,Cui, Ying-She,Sakai, Yusuke,Sakai, Osamu,Hill, Jeanette R.,Wang, Kevin K. W.,Yuen, Po-Wai
, p. 868 - 871 (2007/10/03)
Novel N-arylsulfonyldipeptidyl aldehyde derivatives were prepared by DMSO oxidation from the corresponding dipeptide alcohol, and their potencies as calpain inhibitors were evaluated in vitro. Among them, N-(4-fluorophenylsulfonyl)-L-valyl-L-leucinal (8,