97936-43-1

Basic information

• Product Name: 2-(METHYLTHIO)NICOTINYL CHLORIDE
• Synonyms: 2-(METHYLSULFANYL)NICOTINOYL CHLORIDE;2-(METHYLTHIO)NICOTINOYL CHLORIDE;2-(METHYLTHIO)NICOTINYL CHLORIDE;2-(METHYLTHIO)PYRIDINE-3-CARBONYL CHLORIDE;2-(Methylmercapto)nicotinylchloride;2-(Methylmercapto)pyridine-3-carbonylchloride;2-(Methylthio)pyridine-3-carbonylch];3-Pyridinecarbonyl chloride, 2-(methylthio)- (9CI)
• CAS NO: 97936-43-1
• Molecular Formula: C₇H₆ClNOS
• Molecular Weight: 187.65
• Product Categories: ACIDHALIDE
• Mol File: 97936-43-1.mol
• Article Data: 6

Chemical Properties

• Melting Point: 88-91°C
• Boiling Point: 294.2°C at 760 mmHg
• Flash Point: 131.8°C
• Appearance: /
• Density: 1.35g/cm³
• Vapor Pressure: 0.00164mmHg at 25°C
• Refractive Index: 1.592
• Sensitive: Moisture Sensitive
• BRN: 5506864
• CAS DataBase Reference: 2-(METHYLTHIO)NICOTINYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(METHYLTHIO)NICOTINYL CHLORIDE(97936-43-1)
• EPA Substance Registry System: 2-(METHYLTHIO)NICOTINYL CHLORIDE(97936-43-1)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39
• RIDADR: 3261
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 97936-43-1(Hazardous Substances Data)

Usage

Uses

2-(Methylthio)nicotinoyl Chloride is used in preparation of benzamides as Bcl-3 inhibitors.

InChI:InChI=1/C7H6ClNOS/c1-11-7-5(6(8)10)3-2-4-9-7/h2-4H,1H3

Upstream product

• 74470-23-8 2-(methylthio)nicotinic acid 
• 2942-59-8 2-chloronicotinic acid 
• 38521-46-9 1,2-dihydro-2-thioxo-3-pyridine carboxylic scid 
• 38521-46-9 3-carboxy-2-mercaptopyridine 

Downstream Products

• 97936-31-7 N-(4-methoxyphenyl)-2-(methylthio)nicotinamide 
• 97936-33-9 N-(2,6-Dimethyl-phenyl)-2-methylsulfanyl-nicotinamide 
• 562838-50-0 3-Benzhydryl-1-[[2-(methylthio)-3-pyridinyl]carbonyl]-4-piperidinone 
• 1205684-30-5 C₂₈H₂₆NOPS 
• 1205684-33-8 C₃₃H₂₈NO₂PS 
• 1205684-31-6 C₃₂H₂₆NOPS 
• 1205684-32-7 C₃₃H₂₈NOPS₂ 
• 141841-36-3 2-(methylthio)-N-phenylnicotinamide 
• 1017107-77-5 N-(2-fluorophenyl)-2-(methylthio)nicotinamide 
• 141841-39-6 N-(2-chlorophenyl)-2-(methylthio)nicotinamide 
• 1031170-76-9 N-(2-bromophenyl)-2-(methylthio)nicotinamide 
• 141841-73-8 2-(methylthio)-N-(o-tolyl)nicotinamide 
• 1603827-60-6 2-(methylthio)-N-(2-(trifluoromethyl)phenyl)nicotinamide 
• 1118801-04-9 N-(2,4-dichlorophenyl)-2-(methylthio)nicotinamide 

Relevant articles and documents

Divergence in Ynone Reactivity: Atypical Cyclization by 3,4-Difunctionalization versus Rare Bis(cyclization)

Functionalized ynones can be activated by Tf2C=CH2, which was generated in situ, to form zwitterionic species. These species were trapped in an intramolecular fashion by several nucleophiles to generate two major types of triflones in a divergent manner. Through fine-tuning of the reaction temperature, bis(triflyl)-6-membered- or (triflyl)-5-membered-fused-heterocycles were achieved in reasonable yields in a totally selective manner. In this way, bis(triflyl)flavones, bis(triflyl)thioflavones, bis(triflyl)selenoflavones, (triflyl)benzothienopyrans, (triflyl)benzoselenophenopyrans, (triflyl)vinyl aurones, and (triflyl)pyranoindoles were constructed. Conceivable mechanistic pathways were suggested on the basis of the isolation of several intermediates and the results from control experiments.

Cascade synthesis of new tetracyclic heteroaromatic thieno[2,3-b]pyridine- containing ring systems

Flash vacuum pyrolysis of appropriate stabilised ylides, prepared in a few steps from 2-(methylthio)nicotinic acid, give products containing previously unknown naphtho-, phenanthro-, benzothieno-and benzofuro-fused thieno[2,3-b]pyridine ring systems.

Herbicidal 1-pyridyltetrazolinones

Herbicidal tetrazolinone derivatives of the formula: STR1 in which R1 is alkyl, haloalkyl, cycloalkyl, alkenyl, haloalkenyl, alkynyl or phenyl, and R2 is alkyl, haloalkyl, cycloalkyl, alkenyl, haloalkenyl, alkynyl or phenyl, or R1 and R2 together with the nitrogen atom to which they are bonded form an optionally benzofused heterocyclic ring, which is optionally substituted by C1-4 alkyl, n is 0, 1, 2 or 3, and R3 each independently is nitro, halogen, alkyl, haloalkyl, alkylthio or phenoxy.