97980-71-7

Basic information

• Product Name: [(5-Hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy]-acetic acid
• Synonyms: [(5-Hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy]-acetic acid;2-(5-hydroxy-4-keto-2-phenyl-chromen-7-yl)oxyacetic acid;2-(5-hydroxy-4-oxo-2-phenyl-chromen-7-yl)oxyacetic acid;2-(5-hydroxy-4-oxo-2-phenylchromen-7-yl)oxyacetic acid;2-(5-hydroxy-4-oxo-2-phenyl-chromen-7-yl)oxyethanoic acid;2-[(5-hydroxy-4-oxo-2-phenyl-7-chromenyl)oxy]acetic acid;Oprea1_795401;STOCK1N-08998
• CAS NO: 97980-71-7
• Molecular Formula: C₁₇H₁₂O₆
• Molecular Weight: 312.27358
• Mol File: 97980-71-7.mol
• Article Data: 17

Chemical Properties

• Melting Point: 266-268 °C
• Boiling Point: 590.3±50.0 °C(Predicted)
• Appearance: /
• Density: 1.467±0.06 g/cm3(Predicted)
• PKA: 2.96±0.10(Predicted)
• CAS DataBase Reference: [(5-Hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy]-acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: [(5-Hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy]-acetic acid(97980-71-7)
• EPA Substance Registry System: [(5-Hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy]-acetic acid(97980-71-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 97980-71-7(Hazardous Substances Data)

Usage

Description

[(5-Hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy]-acetic acid is a chemical compound that belongs to the class of organic compounds known as coumarins and derivatives. It is a derivative of coumarin, containing a hydroxy group and an acetic acid residue. [(5-Hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy]-acetic acid has been studied for its potential biological activities, including antioxidant and anticancer properties. Additionally, it has shown potential as a phytochemical compound with pharmacological relevance. The chemical structure of [(5-Hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy]-acetic acid contains a chromen-7-yl group, which is known for its ability to interact with biological targets and impact various physiological processes. Further research is needed to fully understand the potential applications and mechanisms of action of this compound.

Uses

Used in Pharmaceutical Industry:
[(5-Hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy]-acetic acid is used as a potential therapeutic agent for its antioxidant and anticancer properties. [(5-Hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy]-acetic acid's ability to interact with biological targets and impact physiological processes makes it a promising candidate for the development of new drugs to treat various diseases, particularly cancer.
Used in Research and Development:
In the field of scientific research, [(5-Hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy]-acetic acid serves as a valuable compound for studying its biological activities and potential pharmacological applications. Researchers can use this compound to investigate its mechanisms of action, interactions with biological targets, and its potential to be developed into a drug for various medical conditions.
Used in Cosmetics Industry:
Given its antioxidant properties, [(5-Hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy]-acetic acid may also find applications in the cosmetics industry as an ingredient in skincare products. Its antioxidant capabilities could potentially help protect the skin from damage caused by free radicals and promote overall skin health.
Used in Agricultural Industry:
As a phytochemical compound with potential pharmacological relevance, [(5-Hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy]-acetic acid could be utilized in the agricultural industry for the development of new pesticides or other agrochemicals that can help protect crops from pests and diseases while minimizing harm to the environment and human health.

Upstream product

• 84212-46-4 ethyl 2-((5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)acetate 
• 480-40-0 5,7-dihydroxy-2-phenyl-chromen-4-one 
• 314745-06-7 methyl 2-((5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)acetate 
• 90-24-4 2-hydroxy-4,6-dimethoxyacetophenone 
• 480-66-0 2,4,6-trihydroxyacetophenone 
• 33495-30-6 2-benzoyloxy-4,6-dimethoxyacetophenone 
• 33507-94-7 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenylpropane-1,3-dione 
• 21392-57-4 Dimethyl-chrysin 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 1217342-36-3 octadecyl 2-(5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yloxy)acetate 
• 1217342-43-2 N-dodecyl 2-(5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yloxy)acetamide 
• 1217342-44-3 N-tetradecyl 2-(5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yloxy)acetamide 
• 1217342-45-4 N-hexadecyl 2-(5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yloxy)acetamide 
• 1217342-40-9 N-octyl 2-(5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yloxy)acetamide 
• 1217342-30-7 octyl 2-(5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yloxy)acetate 
• 1217342-37-4 icosyl 2-(5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yloxy)acetate 
• 1217342-38-5 N-hexyl-2-(5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yloxy)acetamide 
• 1217342-29-4 heptyl 2-(5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yloxy)acetate 
• 1217342-39-6 N-heptyl 2-(5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yloxy)acetamide 
• 1217342-41-0 N-nonyl 2-(5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yloxy)acetamide 
• 1217342-42-1 N-decyl 2-(5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yloxy)acetamide 
• 1217342-32-9 decyl 2-(5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yloxy)acetate 
• 1217342-33-0 dodecyl 2-(5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yloxy)acetate 

Relevant articles and documents

Inhibiting epidermal growth factor receptor signalling potentiates mesenchymal–epithelial transition of breast cancer stem cells and their responsiveness to anticancer drugs

The recurrence of breast cancer in patients is a persistent challenge to the medical fraternity. Breast tumor contains a small population of cells with high tumor initiating and metastatic potential, known as cancer stem cells (CSCs), which are resistant to existing chemotherapeutics. CSCs contribute to the aggressiveness of triple negative breast cancers (TNBCs), thereby necessitating the identification of molecular targets on breast CSCs. TNBC cell line MDA-MB-231, in comparison with MCF-7, demonstrated a higher expression of epidermal growth factor receptor (EGFR). Thus, the naturally occurring flavanone, chrysin, with limited potential as a chemotherapeutic agent, was structurally modified by designing an analog with EGFR binding affinity using a molecular docking approach and subsequently synthesised. Chrysin analog CHM-09 and known EGFR inhibitors demonstrated a comparable anti-proliferative, anti-migratory activity along with the induction of apoptosis and cell cycle arrest in MDA-MB-231. Furthermore, sorted CD24?/CD44+-breast CSCs and CD24+-breast cancer cells from MDA-MB-231 demonstrated a markedly high expression of EGFR in the former than in the latter. CHM-09 and EGFR inhibitors could perturb EGF-induced EGFR signalling of breast CSC proliferation, migration, mammosphere formation and mesenchymal tri-lineage differentiation. CHM-09 or EGFR inhibitors not only led to inactivation of EGFR downstream signalling pathways such as Akt, extracellular signal regulated kinase and signal transducer and activator of transcription 3, but also induction of mesenchymal–epithelial transition as confirmed by decreased N-cadherin and increased E-cadherin expression. Finally, combinatorial treatment of EGFR inhibitors and doxorubicin led to significant increase in breast CSCs responsiveness to a chemotherapeutic drug. The results of the present study suggest that EGFR is a therapeutic target in breast CSCs and that abrogation of EGFR signalling along with chemotherapeutic drugs is an effective approach against breast cancer.

Long-chain primary amide white poplar derivative as well as preparation method and application thereof

The invention belongs to the field of medicines, and relates to a long-chain primary amide chrysin derivative and a preparation method and application thereof. The long-chain primary amide white poplar derivative has the structure shown I, and in the form

Chrysin amide derivative as well as preparation method and medical application thereof

The invention relates to the technical field of pharmaceutical chemistry and in particular relates to a chrysin amide derivative as well as a preparation method and medical application of the derivative. A structural formula of the chrysin amide derivativ