97990-95-9

Basic information

• Product Name: 1,1,1-Triphenyl-2-propanol
• Synonyms: 1,1,1-Triphenyl-2-propanol
• CAS NO: 97990-95-9
• Molecular Weight: 288.389
• Mol File: 97990-95-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,1,1-Triphenyl-2-propanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1,1-Triphenyl-2-propanol(97990-95-9)
• EPA Substance Registry System: 1,1,1-Triphenyl-2-propanol(97990-95-9)

Safety Data

• Hazardous Substances Data: 97990-95-9(Hazardous Substances Data)

Usage

Physical state

Crystalline solid

Color

White to off-white

Solubility in water

Sparingly soluble

Uses

a. Chiral resolving agent in separation of racemic mixtures
b. Protecting group in organic synthesis
c. Stabilizer for plastics and polymers

Pharmaceutical applications

a. Potential anti-inflammatory agent
b. Potential analgesic agent

Safety precautions

Handle with caution due to potential harmful effects if not used properly

Upstream product

• 34324-92-0 triphenylmethylmagnesium chloride 
• 75-07-0 acetaldehyde 
• 519-73-3 triphenylmethane 
• 795-36-8 1,1,1-triphenylacetone 
• 30615-54-4 triphenylmethyl bromide 
• 97991-03-2 (E)-1,1,1-triphenyl-3-penten-2-one 
• 78167-32-5 4-Methyl-1,1,1-triphenyl-5-undecin-2-on 
• 97990-99-3 (E)-1,1,1-Triphenyl-3-penten-2-ol 

Downstream Products

• 139164-44-6 (R)-1-tritylethanol 
• 103280-67-7 (+/-)-4-nitro-benzoic acid-(1-methyl-2,2,2-triphenyl-ethyl ester) 
• 795-36-8 1,1,1-triphenylacetone 
• 120971-15-5 phthalic acid mono-((R)-1-methyl-2,2,2-triphenyl-ethyl ester) 
• 120971-15-5 phthalic acid mono-((S)-1-methyl-2,2,2-triphenyl-ethyl ester) 
• 143430-71-1 1-t-butyl 5-methyl (1'R,2R,5R)-2-(t-butyl)-3-methyl-5-<1'-methyl-3'-oxo-4',4',4'-triphenylbutyl>-1,5-imidazolidinedicarboxylate 
• 143430-67-5 t-butyl (1'S,2R,5R)-2-(t-butyl)-3-methyl-5-<1'-methyl-3'-oxo-4',4',4'-triphenylbutyl>-4-oxo-1-imidazolidinecarboxylate 
• 143430-69-7 t-butyl (2R)-2-(t-butyl)-3-methyl-5-<1'-methyl-3'-oxo-4',4',4'-triphenylbutyl>-1-imidazolidinecarboxylate 
• 97991-06-5 (E)-4-Hydroxy-2,2,2-triphenyl-5-hepten-2-on 

Relevant articles and documents

Trityl-containing alcohols—an efficient chirality transmission process from inductor to the stereodynamic propeller and their solid-state structural diversity

The cascade process of a dynamic chirality transmission from the permanent chirality center to the stereodynamic triphenylmethyl group has been studied for series of optically active trityl derivatives. The structural analysis, carried out with the use of complementary methods, enabled us to determine the mechanism of chirality transfer. The process of chirality transmission involves a set of weak but complementary electrostatic interactions. The induction of helicity in a trityl propeller is revealed by rising non-zero cotton effects in the area of trityl UV-absorption. The presence of an additional stereogenic center in close proximity to the trityl-containing stereogenic center significantly affects the sign and, to a lesser extent, magnitude of the respective cotton effects. Despite the bulkiness of the trityl, in the crystalline phase, the molecules under study strictly fill the space. In the crystal, molecules form aggregates stabilized by OH???O hydrogen bonds. However, the presence of two trityl groups precludes formation of OH???O hydrogen bonding. Additionally, the trityl group seems to be responsible for the formation of the solid solutions by e.g., racemates of trans- and cis-2-tritylcyclohexanol. Therefore, the trityl group acts as a supramolecular protective group, which in turn can be used in the crystal engineering.

Tritylketones and Tritylenones. Contribution to the Sterically Enforced Michael Addition and to the Diastereoselective Aldol Addition

Tritylketones are prepared from trityllithium and aldehydes, with subsequent CrO3 oxidation (Scheme 1, 2a-f).Tritylenones are obtained from the saturated ketones and aldehydes or ketones, preferably by (CH3)3Al-mediated aldol addition with subsequent dehy