98061-37-1Relevant articles and documents
Cobalt-catalyzed hydroxymethylarylation of terpenes with formaldehyde and arenes
Yang, Jun,Ji, Ding-Wei,Hu, Yan-Cheng,Min, Xiang-Ting,Zhou, Xiangge,Chen, Qing-An
, p. 9560 - 9564 (2019)
Terpenes, consisting of isoprene monomer units, represent a family of naturally abundant compounds. The difunctionalization of terpenes is highly appealing yet remains challenging, since the multiple unbiased CC bonds of terpenes lead to difficulty in controlling the regioselectivity. Herein, a cobalt(iii)-catalyzed C-H activation strategy has been developed to facilitate hydroxymethylarylation of terpenes with formaldehyde and arenes with high chemo- A nd regio-selectivities. These (chemo- A nd regio-) selectivities are governed by the coordination abilities of isoprene, directing groups and the steric effect. This terpene difunctionalization also features high atom and step economy through a C-H addition pathway.
Isoprene: A Promising Coupling Partner in C-H Functionalizations
Zhang, Wei-Song,Hu, Yan-Cheng,Chen, Qing-An
, p. 1649 - 1655 (2020/07/24)
Five-carbon dimethylallyl units, such as prenyl and reverse-prenyl, are widely distributed in natural indole alkaloids and terpenoids. In conventional methodologies, these valuable motifs are often derived from substrates bearing leaving groups, but these
Ru-Catalyzed Regioselective Direct Hydroxymethylation of (Hetero)Arenes via C-H Activation
Zhang, Guo-Fu,Li, Yue,Xie, Xiao-Qiang,Ding, Cheng-Rong
supporting information, p. 1216 - 1219 (2017/03/14)
An efficient and direct ruthenium-catalyzed regioselective hydroxymethylation of (hetero)arenes via C-H activation with paraformaldehyde as a hydroxymethylating reagent is described. The corresponding products can be obtained in good to excellent yield. A number of aryl aldehydes can also be used in place of paraformaldehyde giving the desired alcohol products with similarly good results.
