98079-55-1 Usage
Description
(R)-Lomefloxacin is a synthetic and broad-spectrum antibiotic belonging to the fluoroquinolone class. It is the R-enantiomer of lomefloxacin, which is a second-generation fluoroquinolone that exhibits potent antibacterial activity against a wide range of gram-negative and gram-positive bacteria. It works by inhibiting the activity of bacterial DNA gyrase and topoisomerase IV, thereby preventing DNA replication and transcription, ultimately leading to bacterial cell death.
Uses
Used in Pharmaceutical Industry:
(R)-Lomefloxacin is used as an antibiotic for the treatment of various bacterial infections. It is effective against a wide range of gram-negative and gram-positive bacteria, making it a valuable tool in combating bacterial infections.
Used in Urinary Tract Infections:
(R)-Lomefloxacin is used as a treatment for urinary tract infections, where it helps to eliminate the bacteria causing the infection and alleviates the symptoms.
Used in Respiratory Tract Infections:
(R)-Lomefloxacin is used as a treatment for respiratory tract infections, such as bronchitis and pneumonia, where it targets the bacteria responsible for the infection and aids in recovery.
Used in Skin Infections:
(R)-Lomefloxacin is used as a treatment for skin infections, including those caused by gram-negative and gram-positive bacteria, where it helps to clear the infection and promote healing.
Used in Sexually Transmitted Diseases:
(R)-Lomefloxacin is used as a treatment for certain sexually transmitted diseases, where it targets the bacteria causing the infection and helps to prevent the spread of the disease.
However, it is important to note that the use of (R)-Lomefloxacin is limited due to potential adverse effects such as tendon rupture, peripheral neuropathy, and phototoxicity, as well as the emergence of bacterial resistance.
Check Digit Verification of cas no
The CAS Registry Mumber 98079-55-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,8,0,7 and 9 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 98079-55:
(7*9)+(6*8)+(5*0)+(4*7)+(3*9)+(2*5)+(1*5)=181
181 % 10 = 1
So 98079-55-1 is a valid CAS Registry Number.
98079-55-1Relevant articles and documents
Experimental and computational study on the enantioseparation of four chiral fluoroquinolones by capillary electrophoresis with sulfated-β-cyclodextrin as chiral selector
Ma, Qianyun,Cong, Wei,Liu, Ye,Geng, Zikai,Lin, Ying,Wang, Zhaokun
, p. 549 - 557 (2021/07/20)
In this work, enantioseparation of four chiral fluoroquinolones (FQs), namely, ofloxacin, gemifloxacin, lomefloxacin, and gatifloxacin, was achieved by capillary electrophoresis with sulfated-β-cyclodextrin (S-β-CD) as chiral selector. Factors affecting the enantiomeric resolution, such as the concentrations of S-β-CD, BGE pH conditions, and the buffer types and concentrations, were optimized and discussed. A BGE consisting of 30 g/L S-β-CD and 30-mM phosphate at pH?4.0 was found fit for enantiomeric resolution of ofloxacin and gemifloxacin, while the same BGE at pH?3.0 was suitable for enantioseparation of lomefloxacin and gatifloxacin. The pH-dependent experiments showed that separation resolutions of four FQs enantiomers were significantly affected by BGE pH, which was thought to be related with the varying electrostatic attraction between the enantiomers and chiral selector. To verify this speculation, molecular docking studies were used for further investigation of the enantiomeric recognition mechanism of S-β-CD. Molecular model indicated that hydrophobic effect and hydrogen bond were involved in host-guest inclusion, but the electrostatic attraction enhanced the chiral discrimination by increasing the difference in binding energy between individual enantiomers and S-β-CD. This work provided a further insight into the chiral recognition mechanisms of CD derivatives.
