98079-83-5 Usage
Description
1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid ethyl ester is a chemical compound that is an impurity of Lomefloxacin (L469415), a fluorinated quinolone antibacterial agent and a DNA gyrase antagonist.
Uses
Used in Pharmaceutical Industry:
1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid ethyl ester is used as an impurity in Lomefloxacin, a fluorinated quinolone antibacterial agent, for its role in DNA gyrase inhibition and antibacterial properties.
Check Digit Verification of cas no
The CAS Registry Mumber 98079-83-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,8,0,7 and 9 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 98079-83:
(7*9)+(6*8)+(5*0)+(4*7)+(3*9)+(2*8)+(1*3)=185
185 % 10 = 5
So 98079-83-5 is a valid CAS Registry Number.
98079-83-5Relevant articles and documents
Regioselective nucleophilic substitution of halogen derivatives of 1-substituted 4-oxo-1,4-dihydroquinoline-3-carboxylic acids
Hermecz, Istvan,Vasvari-Debreczy, Lelle,Podanyi, Benjamin,Kereszturi, Geza,Balogh, Maria,Horvath, Agnes,Varkonyi, Peter
, p. 1111 - 1116 (2007/10/03)
The rate of the nucleophilic displacement of the fluoro atom of 7-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate could be enhanced either by the introduction of further fluoro atom(s) into position(s) 6 and/or 8, or by the formation of a boron chelate (e.g. 3). The regioselectivity of the nucleophilic substitution of the chloro atom in 1-substituted 6-fluoro-7-chloro-4-oxo-1,4dihydroquinoline-3-carboxylic acids could also be enhanced by the formation of a boron chelate (e.g. 7).
