98081-76-6

Basic information

• Product Name: 2-Propenoic acid, 2-azido-3-(4-chlorophenyl)-, methyl ester
• CAS NO: 98081-76-6
• Molecular Formula: C10H8ClN3O2
• Molecular Weight: 237.645
• Mol File: 98081-76-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 2-azido-3-(4-chlorophenyl)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 2-azido-3-(4-chlorophenyl)-, methyl ester(98081-76-6)
• EPA Substance Registry System: 2-Propenoic acid, 2-azido-3-(4-chlorophenyl)-, methyl ester(98081-76-6)

Safety Data

• Hazardous Substances Data: 98081-76-6(Hazardous Substances Data)

Upstream product

• 7560-44-3 methyl 4-chlorocinnamate 
• 1816-92-8 Methyl azidoacetate 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 98081-84-6 6-chloro-2-methoxycarbonylindole 
• 1621106-11-3 methyl 4-(4-chlorophenyl)-3-(p-tolyl)isoxazole-5-carboxylate 
• 98081-81-3 methyl 2-(4-chlorophenyl)-2H-azirine-3-carboxylate 
• 186700-30-1 methyl 3-(4-chlorophenyl)-2-hydroxypropanoate 
• 1529806-73-2 N-((1-benzyl-6-chloro-1H-indol-2-yl)methyl)-4-methyl-N-(3-(2-methyl-1-tosylaziridin-2-yl)-prop-2-ynyl)benzenesulfonamide 
• 1529806-92-5 9-benzyl-7-chloro-4'-methyl-1',2-ditosyl-1,1',2,3,5',9-hexa-hydrospiro[pyrido[3,4-b]indole-4,2'-pyrrole] 
• 1584221-47-5 C₂₃H₂₁ClN₂O₂S 
• 1584221-46-4 C₂₃H₁₉ClN₂O₂S 
• 1584221-45-3 C₁₆H₁₂ClNO 
• 1584221-43-1 C₁₆H₁₄ClNO 
• 1584221-42-0 C₁₇H₁₄ClNO₂ 
• 1372412-01-5 methyl 4-(4-chloro-phenyl)-1,5-dioxo-2,5-dihydro-1H-benzo[c]azepine-3-carboxylate 
• 1372411-86-3 methyl 4-(4-chloro-phenyl)-5-hydroxy-1-oxo-2,5-dihydro-1H-benzo[c]azepine-3-carboxylate 

Relevant articles and documents

Synthesis of 3,4,5-trisubstituted isoxazoles by the 1,3-dipolar cycloaddition reaction of α-azido acrylates and aromatic oximes

A novel, one-pot, cascade reaction sequence featuring the 1,3-dipolar cycloaddition reaction of α-azido acrylates and aromatic oximes was developed. This procedure provides an efficient, straightforward and metal-free method for the synthesis of 3,4,5-trisubstituted isoxazoles under mild reaction conditions.

Extending the versatility of the Hemetsberger-Knittel indole synthesis through microwave and flow chemistry

Microwave, flow and combination methodologies have been applied to the synthesis of a number of substituted indoles. Based on the Hemetsberger-Knittel (HK) process, modifications allow formation of products rapidly and in high yield. Adapting the methodology allows formation of 2-unsubstituted indoles and derivatives, and a route to analogs of the antitumor agent PLX-4032 is demonstrated. The utility of the HK substrates is further demonstrated through bioconjugation and subsequent ring closure and via Huisgen type [3+2] cycloaddition chemistry, allowing formation of peptide adducts which can be subsequently labeled with fluorine tags.