98137-94-1

Basic information

• Product Name: Benzene, 2-bromo-1,3-dichloro-5-nitro-
• CAS NO: 98137-94-1
• Molecular Formula: C6H2BrCl2NO2
• Molecular Weight: 270.897
• Mol File: 98137-94-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzene, 2-bromo-1,3-dichloro-5-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 2-bromo-1,3-dichloro-5-nitro-(98137-94-1)
• EPA Substance Registry System: Benzene, 2-bromo-1,3-dichloro-5-nitro-(98137-94-1)

Safety Data

• Hazardous Substances Data: 98137-94-1(Hazardous Substances Data)

Upstream product

• 99-30-9 4-nitro-2,6-dichloroaniline 
• 401631-95-6 C₁₀H₁₂Cl₂N₄O₂ 

Downstream Products

• 6149-58-2 2,6-dichloro-N,N-dimethyl-4-nitro-aniline 
• 183603-62-5 α-(4-chlorophenyl)-α-(2,6-dichloro-4-nitrophenyl)methane 
• 180253-72-9 (2,6-dichloro-4-nitrophenyl)(phenyl)sulfane 

Relevant articles and documents

BIARYL UREA DERIVATIVE OR SALT THEREOF, AND MANUFACTURING AND APPLICATION OF SAME

The present invention discloses a biaryl urea RORγt inhibitor, and specifically relates to a biaryl urea derivative, as represented by formula I, with an RORγt inhibiting activity, and a preparation process thereof, and a pharmaceutical composition comprising the compound. Further disclosed is use of the compound for treating an RORγt-related disease.

1-Aryl-3,3-dialkyltriazenes: A convenient synthesis from dry arenediazonium o-benzenedisulfonimides - A high yield break down to the starting dry salts and efficient conversions to aryl iodides, bromides and chlorides

This research comprises three parts. The first part regards the synthesis of 1-aryl-3,3-dialkyltriazenes 3 by reaction of dry arenediazonium o-benzenedisulfonimides 1, also coming from weakly basic aromatic amines with dimethylamine or diethylamine in aqueous solution at 0-5 °C. Yields were usually greater than 90% and there was the possibility of recovering the o-benzenedisulfonimide (5), which could be reused to prepare the salts 1. In the second part it was demonstrated that there is the possibility of reconverting the triazenes 3 into the starting stable dry salts 1 by using 5 as acid. The reactions were carried out in glacial acetic acid at 50-55 °C and normally afforded salts 1 in yields of around 90-99%. The third part concerns the setting up of two procedures for the conversion of 3 to aryl iodides 9, bromides 10 and chlorides 11. Procedure A used the corresponding aqueous hydrogen halides in acetonitrile at r.t. or 60 °C, sometimes in the presence of aqueous HBF4, sometimes Cu powder (25 examples, yields 65%-88%). Procedure B usually used anhydrous methanesulfonic acid and tetraalkylammonium halides in anhydrous acetonitrile at temperatures varying from r.t. to 80 °C, sometimes in the presence of Cu (16 examples, yields 65-88%).