98192-14-4

Basic information

• Product Name: 2-Bromo-N-methylbenzenesulphonamide
• Synonyms: 2-Bromo-N-methylbenzenesulphonamide;N-Methyl 2-bromobenzenesulphonamide;2-Bromo-N-methylbenzenesulphonamide 98%;2-Bromo-N-methylbenzenesulfonamide;N-Methyl 2-bromobenzenesulfonamide;2-Bromo-N-methylbenzenesulphonamide98%
• CAS NO: 98192-14-4
• Molecular Formula: C₇H₈BrNO₂S
• Molecular Weight: 250.11292
• Product Categories: blocks;Bromides;Sulfonamides
• Mol File: 98192-14-4.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 341.9 °C at 760mmHg
• Flash Point: 160.6 °C
• Appearance: /
• Density: 1.601 g/cm³
• Vapor Pressure: 7.8E-05mmHg at 25°C
• Refractive Index: 1.574
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-Bromo-N-methylbenzenesulphonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-N-methylbenzenesulphonamide(98192-14-4)
• EPA Substance Registry System: 2-Bromo-N-methylbenzenesulphonamide(98192-14-4)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 98192-14-4(Hazardous Substances Data)

Usage

General Description

2-Bromo-N-methylbenzenesulphonamide is a chemical compound that belongs to the class of benzenesulfonamides. It is a white solid with the molecular formula C7H8BrNO2S, and it is commonly used in the synthesis of pharmaceuticals and agrochemicals. 2-Bromo-N-methylbenzenesulphonamide is known for its antimicrobial properties and has been used as an antibacterial and antifungal agent in various applications. It is also utilized as a reagent in organic synthesis, particularly in the preparation of sulfonamides and related compounds. 2-Bromo-N-methylbenzenesulphonamide is considered to be a valuable intermediate in the production of various pharmaceutical products and plays an important role in the pharmaceutical and chemical industries.

InChI:InChI=1/C7H8BrNO2S/c1-9-12(10,11)7-5-3-2-4-6(7)8/h2-5,9H,1H3

Upstream product

• 2905-25-1 o-bromobenzenesulfonyl chloride 
• 74-89-5 methylamine 
• 7154-66-7 2-bromobenzoic acid chloride 
• 88-21-1 2-amino-1-benzenesulfonic acid 
• 576-92-1 bromobenzene-2-sulfonic acid 
• 593-51-1 methylamine hydrochloride 
• 5183-78-8 methyl(phenylsulfonyl)amide 
• 80-43-3 bis(1-methyl-1-phenylethyl)peroxide 
• 92748-09-9 2-bromobenzene-1-sulfonamide 

Downstream Products

• 1153687-22-9 N-benzyl-2-bromo-N-methylbenzenesulfonamide 
• 1153687-20-7 2-bromo-N-(4-methoxybenzyl)-N-methylbenzenesulfonamide 
• 1186611-27-7 C₁₂H₁₇NO₂SSi 
• 1269616-18-3 2-bromo-N-methyl-N-(prop-2-ynyl)benzenesulfonamide 
• 1578268-75-3 C₁₆H₁₈FNO₂S 
• 51193-20-5 N-methyl-2-vinylbenzenesulfonamide 
• 1628741-45-6 2-deutero-N-methylbenzenesulfonamide 
• 1628741-00-3 N-(2-deuterophenylsulfonyl)-N-methylmethacrylamide 
• 1628741-44-5 2-deutero-N-(4-methoxybenzyl)-N-methylbenzene sulfonamide 

Relevant articles and documents

Synthesis of novel isoflavone/benzo-δ-sultam hybrids as potential anti-inflammatory drugs

A small series of novel isoflavone/benzo-δ-sultam hybrids was synthesised and evaluated as potential anti-inflammatory and neuroprotective drugs in LPS-activated BV2 microglia. The benzo-δ-sultam core was constructed in a two-step reaction by coupling 2-halobenzenesulfonamide derivatives with terminal alkynes, followed by a 6-endo-dig cyclisation. The synthesised compounds, including precursors and hybrids, were tested for their ability to inhibit NO and TNF-α production in LPS-stimulated BV2 microglial cells, and the results are promising. The most potent hybrid reduces the NO production to 41%, and the TNF-α to 34% at 20 μM final concentration in the well.

Cobalt-Catalyzed 1,4-Aryl Migration/Desulfonylation Cascade: Synthesis of α-Aryl Amides

A cobalt-catalyzed 1,4-aryl migration/disulfonylation cascade applied to α-bromo N-sulfonyl amides was developed. The reaction was highly chemoselective, allowing the preparation of α-aryl amides possessing a variety of functional groups. The method was used as the key step to synthesize an alkaloid, (±)-deoxyeseroline. Mechanistic investigations suggest a radical process.

Nickel-catalyzed regioselective C-H halogenation of electron-deficient arenes

A straightforward Ni(ii)-catalyzed general strategy was developed for the ortho-halogenation of electron-deficient arenes with easily available halogenating reagents N-halosuccinimides (NXS; X = Br, Cl and I). The transformation was highly regioselective and a wide substrate scope and functional group tolerance were observed. This discovery could be of great significance for the selective halogenation of amides, benzoic esters and other substances with guiding groups. Mechanistic investigations were also described.