98198-73-3

Basic information

• Product Name: 6-chloro-2-(methylthio)pyridin-3-amine
• Synonyms: 6-chloro-2-(methylthio)pyridin-3-amine
• CAS NO: 98198-73-3
• Molecular Weight: 174.654
• Mol File: 98198-73-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-chloro-2-(methylthio)pyridin-3-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-2-(methylthio)pyridin-3-amine(98198-73-3)
• EPA Substance Registry System: 6-chloro-2-(methylthio)pyridin-3-amine(98198-73-3)

Safety Data

• Hazardous Substances Data: 98198-73-3(Hazardous Substances Data)

Upstream product

• 4548-45-2 2-chloro-5-nitropyridine 
• 353-43-5 boron dimethyl-trifluoro sulphide 

Relevant articles and documents

BF3·SMe2 for Thiomethylation, Nitro Reduction and Tandem Reduction/SMe Insertion of Nitrogen Heterocycles

Herein, a general, solvent-free and straightforward thiomethylation of electron deficient heterocycles using BF3·SMe2 as a dual thiomethyl source and Lewis acidic activator is presented. A range of heterocycles including pyrimidine, pyrazine, pyridazine, thiazole and purine derivatives were successfully substituted using this method. An unexpected reductive property of BF3·SMe2 towards nitropyridines was also discovered including an intriguing tandem reduction/SMe insertion process in certain substrates. Notable features of the present work include its convenience and use of a non-malodorous reagent while the discovery of novel chemical transformations using BF3·SMe2 provides fundamental new insights into the reactivity of this commonly employed reagent.