98203-04-4Relevant articles and documents
Activation of 6-bromoquinoline by nitration: Synthesis of morpholinyl and piperazinyl quinolones
?akmak, Osman,?kten, Salih,Alimli, Dilek,Saddiqa, Aisha,Ersanli, Cem C?neyt
, p. 362 - 374 (2018/07/05)
Quinoline forms the key skeletal component of a number of important natural products and pharmacologically-Active compounds. Despite a tremendous amount of research pertaining to the derivatization of quinoline, very few general synthetic routes are described in the literature starting from quinoline or tetrahydroquinoline. A simple and convenient method for the polyfunctionalization of quinolines via nitration of bromoquinolines has been developed. This method represents a new synthetic approach to convert brominated nitroquinoline derivatives into useful cyclic amines via nucleophilic-substitution (SNAr) reaction. Formula parented.
A Mild and General Larock Indolization Protocol for the Preparation of Unnatural Tryptophans
Chuang, Kangway V.,Kieffer, Madeleine E.,Reisman, Sarah E.
supporting information, p. 4750 - 4753 (2016/09/28)
A mild and general protocol for the Pd(0)-catalyzed heteroannulation of o-bromoanilines and alkynes is described. Application of a Pd(0)/P(tBu)3 catalyst system enables the efficient coupling of o-bromoanilines at 60 °C, mitigating deleterious side reactions and enabling access to a broad range of useful unnatural tryptophans. The utility of this new protocol is demonstrated in the highly convergent total synthesis of the bisindole natural product (-)-aspergilazine A.