98258-74-3

Basic information

• Product Name: Benzene, 1-methoxy-4-nitro-5-(2-nitroethenyl)-2-(phenylmethoxy)-, (E)-
• CAS NO: 98258-74-3
• Molecular Formula: C16H14N2O6
• Molecular Weight: 330.297
• Mol File: 98258-74-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzene, 1-methoxy-4-nitro-5-(2-nitroethenyl)-2-(phenylmethoxy)-, (E)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-methoxy-4-nitro-5-(2-nitroethenyl)-2-(phenylmethoxy)-, (E)-(98258-74-3)
• EPA Substance Registry System: Benzene, 1-methoxy-4-nitro-5-(2-nitroethenyl)-2-(phenylmethoxy)-, (E)-(98258-74-3)

Safety Data

• Hazardous Substances Data: 98258-74-3(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 121-33-5 vanillin 
• 2426-87-1 3-methoxy-4-(phenylmethoxy)benzaldehyde 
• 75-52-5 nitromethane 
• 2426-84-8 4-(benzyloxy)-5-methoxy-2-nitrobenzaldehyde 
• 63909-38-6 1-(benzyloxy)-2-methoxy-4-[(E)-2-nitroethenyl]benzene 

Downstream Products

• 2380-82-7 6-hydroxy-5-methoxy indole 
• 98258-76-5 (E)-4-hydroxy-5-methoxy-2,β-dinitrostyrene 

Relevant articles and documents

Syntheses of NAMDA derivatives inhibiting NO production in BV-2 cells stimulated with lipopolysaccharide

Sixteen derivatives of N-acetyl-3-O-methyldopamine (NAMDA), an inhibitor of BH4 synthesis, were designed and synthesized. The ability of these derivatives to inhibit NO and BH4 production by lipopolysaccharide- stimulated BV-2 microglial cells was determined. While NAMDA at 100 μM inhibited NO and BH4 production by only about 20%, its catecholamide 8, indole 23 derivative, 13, and N-acetyl tetrahydroisoquinoline 25 inhibited the NO production by >50% at the same concentration. In particular, 13 and 25 inhibited both NO and BH4 production to similar degrees, which suggested that these compounds might inhibit NO production by blocking BH 4-dependent dimerization of the newly synthesized iNOS monomer.