98280-45-6

Basic information

• Product Name: Benzenecarboximidamide, 2-amino-4-chloro-N-hydroxy-
• CAS NO: 98280-45-6
• Molecular Formula: C7H8ClN3O
• Molecular Weight: 185.613
• Mol File: 98280-45-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzenecarboximidamide, 2-amino-4-chloro-N-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenecarboximidamide, 2-amino-4-chloro-N-hydroxy-(98280-45-6)
• EPA Substance Registry System: Benzenecarboximidamide, 2-amino-4-chloro-N-hydroxy-(98280-45-6)

Safety Data

• Hazardous Substances Data: 98280-45-6(Hazardous Substances Data)

Upstream product

• 38487-86-4 2-amino-4-chlorobenzonitrile 

Downstream Products

• 478489-03-1 3-(2-Amino-4-chloro-phenyl)-5-(3-chloro-thiophen-2-yl)-[1,2,4]-oxadiazole 
• 599191-63-6 N-[6-chloro-1H-indazol-3-yl]benzenamide 
• 697278-41-4 3-(2-amino-4-chlorophenyl)-4H-[1,2,4]oxadiazol-5-one 

Relevant articles and documents

Substrate-Independent High-Throughput Assay for the Quantification of Aldehydes

The selective and direct reduction of carboxylic acids into the corresponding aldehydes by chemical methods is still a challenging task in synthesis. Several reductive and oxidative chemical methods are known to produce aldehydes, but most of them require

Synthetic studies toward 3-(acylamino)-1 H-indazoles and development of a one-pot, microwave-assisted, oxadiazole condensation/Boulton-Katritzky rearrangement

Studies on the Boulton-Katritzky rearrangement of 3-(2-aminoaryl)-1,2,4- oxadiazoles have led to the identification of additional electronic factors that govern the rearrangement as well as a competitive thermal rearrangement pathway for select substrates

Bioisosteric modifications of 2-arylureidobenzoic acids: Selective noncompetitive antagonists for the homomeric kainate receptor subtype GluR5

2-Arylureidobenzoic acids (AUBAs) have recently been presented as the first series of selective noncompetitive GluR5 antagonists. In this paper we have modified the acidic moiety of the AUBAs by introducing different acidic and neutral groups, and similarly, we have replaced the urea linker of the AUBAs with other structurally related linkers. Replacing the acid with neutral substituents led to inactive compounds in all instances, showing that an acidic moiety is necessary for activity. Replacing the carboxylic moiety in 2a with a sulfonic acid (5c) or a tetrazole ring (5d) improved the potency at GluR5 receptors (compounds 5c and 5d showed IC50 values of 1.5 and 2.0 μM, respectively, compared to compound 2a with IC50 = 4.8 μM). Compound 5c did not show improved in vivo activity in the ATPA rigidity test compared to 2a, whereas compound 5d was 4 times more potent than 2a. All compounds wherein the urea linker had been replaced showed lower or no activity. The results described extend the knowledge of structure-activity relationships for the AUBAs, and compound 5d may prove to be a good candidate for studying GluR5 receptors in vitro and in vivo.