98420-98-5

Basic information

• Product Name: 4-Bromo-2-phenylpyridine
• Synonyms: 4-Bromo-2-phenylpyridine;4-Bromo-2-phenylypridine;Pyridine, 4-broMo-2-phenyl-
• CAS NO: 98420-98-5
• Molecular Formula: C₁₁H₈BrN
• Molecular Weight: 234.09
• Mol File: 98420-98-5.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 4-Bromo-2-phenylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-2-phenylpyridine(98420-98-5)
• EPA Substance Registry System: 4-Bromo-2-phenylpyridine(98420-98-5)

Safety Data

• Hazardous Substances Data: 98420-98-5(Hazardous Substances Data)

Usage

Uses

4-Bromo-2-phenylpyridine can be used to prepare NLRP3 inhibitors to treat various diseases.

Upstream product

• 98420-86-1 4-Bromo-2-phenyl-2H-pyridine-1-carboxylic acid phenyl ester 
• 58530-53-3 2,4-dibromopyridine 
• 98-80-6 phenylboronic acid 
• 100-59-4 phenylmagnesium chloride 
• 19524-06-2 4-bromopyridine hydrochloride 
• 24388-23-6 2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole 
• 603-33-8 triphenylbismuthane 
• 100-58-3 phenylmagnesium bromide 
• 30766-03-1 4-bromo-2-picolinic acid 
• 71-43-2 benzene 

Downstream Products

• 26274-35-1 2,4-diphenylpyridine 
• 1105678-72-5 3-{[(1R)-1-phenylethyl]amino}-4-[(2-phenylpyridin-4-yl)amino]cyclobut-3-ene-1,2-dione 
• 1323916-90-0 2-(5-chloro-2-fluoro-phenyl)-4-(2-phenyl-pyridin-4-yl)-[1,8]naphthyridine 
• 1328906-43-9 C₃₂H₃₅NO₂ 
• 1422374-71-7 2-phenyl-4-(2-(2-phenylpyridin-4-yl)ethynyl)pyridine 
• 1422374-72-8 4-ethynyl-2-phenylpyridine 
• 1422374-69-3 2-phenyl-4-(4-(2-phenylpyridin-4-yl)phenyl)pyridine 
• 1422375-02-7 2-phenyl-4((trimethylsilyl)ethynyl)pyridine 
• 1215281-24-5 [2-(4-phenyl-2-pyridinyl-κN)phenyl-κC]bis[2-(2-pyridinyl-κN)phenyl-κC]iridium(III) 
• 879291-26-6 2-(2-phenylpyridin-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 

Relevant articles and documents

A Dichotomy in Cross-Coupling Site Selectivity in a Dihalogenated Heteroarene: Influence of Mononuclear Pd, Pd Clusters, and Pd Nanoparticles-The Case for Exploiting Pd Catalyst Speciation

Site-selective dihalogenated heteroarene cross-coupling with organometallic reagents usually occurs at the halogen proximal to the heteroatom, enabled by intrinsic relative electrophilicity, particularly in strongly polarized systems. An archetypical exam

Transition-Metal-Free Decarboxylative Arylation of 2-Picolinic Acids with Arenes under Air Conditions

A facile, transition-metal-free, and direct decarboxylative arylation of 2-picolinic acids with simple arenes is described. The oxidative decarboxylative arylation of 2-picolinic acids with arenes proceeds readily via N-chloro carbene intermediates to afford 2-arylpyridines in satisfactory to good yields under transition-metal-free conditions. This new type of decarboxylative arylation is operationally simple and scalable and exhibits high functional-group tolerance. Various synthetically useful functional groups, such as halogen atoms, methoxycarbonyl, and nitro, remain intact during the decarboxylative arylation of 2-picolinic acids.

Triarylbismuthanes as threefold aryl-transfer reagents in regioselective cross-coupling reactions with bromopyridines and quinolines

Cross-coupling studies using bromopyridines and bromoquinolines with triarylbismuths as threefold coupling reagents in substoichiometric amounts under Pd-catalysed conditions are disclosed. The reactivity was high with both mono- and dibromopyridyl substrates, and mono- and bis-couplings were carried out regioselectively. A library of monoaryl and diaryl pyridines was formed in high yields. A one-pot strategy provided a simple and straightforward synthesis of both symmetrical and unsymmetrical diarylpyridines. Arylations of 2-bromo- and 3-bromoquinolines were achieved with triarylbismuth reagents. This study demonstrates that triarylbismuths may be used as threefold arylating reagents for the synthesis of aryl pyridines and quinolines through couplings with bromopyridines and bromoquinolines under Pd-catalysed conditions. Copyright