98441-29-3

Basic information

• Product Name: 3(2H)-Pyridazinone, 4-phenyl-
• CAS NO: 98441-29-3
• Molecular Formula: C10H8N2O
• Molecular Weight: 172.186
• Mol File: 98441-29-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 3(2H)-Pyridazinone, 4-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 3(2H)-Pyridazinone, 4-phenyl-(98441-29-3)
• EPA Substance Registry System: 3(2H)-Pyridazinone, 4-phenyl-(98441-29-3)

Safety Data

• Hazardous Substances Data: 98441-29-3(Hazardous Substances Data)

Upstream product

• 1677-79-8 4-chloro-2,3-dihydropyridazin-3-one 
• 98-80-6 phenylboronic acid 
• 5292-53-5 diethyl benzalmalonate 
• 99558-15-3 diethyl 2-formyl-3-phenylbutanedioate 
• 99558-18-6 5-ethoxy-4,5-dihydro-3-phenylfuran-2(3H)-one 
• 100-52-7 benzaldehyde 
• 140-29-4 phenylacetonitrile 
• 34861-81-9 diethyl phenylsuccinate 
• 92500-59-9 α-(2,2-diethoxyethyl)benzyl cyanide 
• 14025-83-3 3-cyano-3-phenylpropanoic acid ethyl ester 
• 635-51-8 2-phenylsuccinic acid 
• 66661-73-2 5-Hydroxy-3-phenyl-dihydro-furan-2-one 
• 103-82-2 phenylacetic acid 
• 99558-16-4 4,5-dihydro-4-phenylpyridazin-3(2H)-one 

Downstream Products

• 1174673-79-0 C₁₄H₁₄N₂O₃ 
• 1174673-75-6 C₁₇H₁₄N₂O 
• 1174673-85-8 C₁₄H₁₆N₂O 
• 138366-14-0 8-Phenyltetrazolo<1,5-b>pyridazine 
• 86663-07-2 4-Phenyl-3-chloropyridazine 

Relevant articles and documents

SIGMA-1 RECEPTOR LIGANDS AND THERAPEUTIC USES THEREOF

The present invention relates to the field of medicine. More specifically, the present invention relates to compounds that are sigma-1 receptor agonists and their use for the treatment of central nervous system disorders, including cognitive or neurodegen

PYRIDAZINES - 61. UNEXPECTED REACTION BEHAVIOR OF PYRIDAZINECARBONITRILE DERIVATIVES TOWARDS PHENYLMAGNESIUM CHLORIDE

Reactions of 4-cyano-3(2H)-pyridazonone (1) and tetrazolopyridazine-8-carbonitrile (4) with phenylmagnesium chloride were found to be governed by formal replacement of the nitrile function to afford the phenyl-substituted pyridazine derivatives 3 a

PREPARATION AND SOME REACTIONS OF 4- AND 5-ARYL-4,5-DIHYDROPYRIDAZIN-3(2H)-ONES

Efficient preparations of 4- and 5-phenyl-4,5-dihydropyridazin-3(2H)-ones have been developed, the main reactions of these compounds have been studied, and the synthetic routes have been used to give analogues with substituents in the phenyl rings.In the best synthesis of the 4-phenyldihyropyridazinone (72 percent overall yield) the product was obtained from phenylacetic acid by three simple stages.This approach was applied in preparations of the 2- and 4-hydroxyphenyl compounds and, in conjunction with a recent method for amine protection, the 4-aminophenyl analogue.A four stage synthesis starting from benzaldehyde gave the 5-phenyldihydropyridazinone in 47 percent overall yield; hydroxybenzaldehydes were similarly converted into 5-(allyloxyphenyl)dihydropyridazinones.Oxidation to phenylpyridazinones occured more readily with the 4- and 5-phenyldihydropyridazinones than with the 6-phenyl isomer.The 4- and 5-dihydropyridazinones were smoothly reduced to tetrahydropyridazinones by hydrogenation over platinum but were uneffected by palladium in the presence of hydrazine or cyclohexene.