98447-30-4

Basic information

• Product Name: 3-BROMO-4-NITROANISOLE
• Synonyms: 2-Bromo-4-methoxynitrobenzene;3-Methoxy-6-nitrobromobenzene
• CAS NO: 98447-30-4
• Molecular Formula: C₇H₆BrNO₃
• Molecular Weight: 232.03
• Product Categories: Aromatic Halides (substituted)
• Mol File: 98447-30-4.mol
• Article Data: 17

Chemical Properties

• Melting Point: 69℃
• Boiling Point: 279.409°C at 760 mmHg
• Flash Point: 122.783°C
• Appearance: /
• Density: 1.64g/cm³
• Vapor Pressure: 0.007mmHg at 25°C
• Refractive Index: 1.581
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-BROMO-4-NITROANISOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-4-NITROANISOLE(98447-30-4)
• EPA Substance Registry System: 3-BROMO-4-NITROANISOLE(98447-30-4)

Safety Data

• Hazardous Substances Data: 98447-30-4(Hazardous Substances Data)

Usage

General Description

3-Bromo-4-Nitroanisole is a chemical compound with the molecular formula C7H6BrNO4. It is a yellow to orange crystalline powder with a molecular weight of 219.03 g/mol. The compound is used in the synthesis of pharmaceuticals and agrochemicals. It is also used as an intermediate in organic synthesis, particularly in the production of dyes and pigments. 3-Bromo-4-Nitroanisole is considered to be a hazardous chemical and should be handled with care, as it can cause irritation to the skin, eyes, and respiratory system upon contact or inhalation.

InChI:InChI=1/C7H6BrNO3/c1-12-5-2-3-7(9(10)11)6(8)4-5/h2-4H,1H3

Upstream product

• 5470-65-5 3-bromo-4-nitrophenol 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 
• 16133-49-6 5-methoxy-2-nitroaniline 
• 2398-37-0 3-methoxyphenyl bromide 
• 591-20-8 3-Bromophenol 
• 96-96-8 4-methoxy-2-nitroaniline 
• 1882-69-5 5-methoxy-2-nitro-benzoic acid 
• 67-56-1 methanol 
• 700-36-7 2-bromo-4-fluoronitrobenzene 
• 43192-31-0 2-bromo-4-methoxybenzaldehyde 
• 124-41-4 sodium methylate 

Downstream Products

• 875241-65-9 4-methoxy-1-nitro-2-phenoxybenzene 
• 872807-72-2 N⁴,N⁴-diethyl-N¹-(5-methoxy-2-nitro-phenyl)-1-methyl-butanediyldiamine 
• 126759-31-7 2-vinyl-4-methoxynitrobenzene 
• 98447-16-6 dimethyl-2,5 nitro-2' methoxy-5' diphenylamine 
• 32338-02-6 2-bromo-4-methoxyaniline 
• 36242-53-2 1-methoxy-3-phenylamino-4-nitrobenzene 
• 338948-37-1 6-(5-methoxy-2-nitrophenyl)-2,3-dimethoxynaphthalene 
• 338948-39-3 6-(2-amino-5-methoxyphenyl)-2,3-dimethoxynaphthalene 
• 1006-94-6 5-methoxylindole 
• 98447-17-7 dimethyl-2,5 amino-2' methoxy-5' diphenylamine 
• 98447-18-8 (dimethyl-2,5 phenyl)-1 1H-methoxy-6 benzotriazole 
• 126759-39-5 2-<(6-methoxy-2-nitrophenyl)methyl>-1,3-dioxane 
• 116707-99-4 1,3-dimethyl-5-methoxyindolin-2-one 
• 79069-37-7 1-(acetamino)-2-bromo-4-methoxybenzene 

Relevant articles and documents

Nitration of deactivated aromatic compounds via mechanochemical reaction

A variety of deactivated arenes were nitrated to their corresponding nitro derivatives in excellent yields under high-speed ball milling condition using Fe(NO3)3·9H2O/P2O5 as nitrating reagent. A radical involved mechanism was proposed for this facial, eco-friendly, safe, and effective nitration reaction.

Inexpensive NaX (X = I, Br, Cl) as a halogen donor in the practical Ag/Cu-mediated decarboxylative halogenation of aryl carboxylic acids under aerobic conditions

Versatile and practical Ag/Cu-mediated decarboxylative halogenation between readily available aryl carboxylic acids and abundant NaX (X = I, Br, Cl) has been achieved under aerobic conditions in moderate to good yields. The halodecarboxylation is shown to be an effective strategy for S-containing heteroaromatic carboxylic acid and benzoic acids with nitro, chloro and methoxyl substituents at the ortho position. A gram-scale reaction and a three-step procedure to synthesize iniparib have been performed to evaluate the practicality of this protocol. A preliminary mechanistic investigation indicates that Cu plays a vital role and a radical pathway is involved in the transformation.

PYRIMIDINES AND VARIANTS THEREOF, AND USES THEREFOR

The present disclosure provides pyrimidine compounds and uses thereof, for example, for the treatment of diseases associated with P2X purinergic receptors. In certain aspects, the present disclosure provides P2X3 and/or P2X2/3 antagonists which are useful, for example, for the treatment of visceral organ, cardiovascular and pain-related diseases, conditions and disorders.