98468-19-0

Basic information

• Product Name: 2-isopropyl-4-methoxy-9-methyl-2,3-dihydro-furo[2,3-b]quinolinium; iodide
• CAS NO: 98468-19-0
• Molecular Weight: 385.245
• Mol File: 98468-19-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-isopropyl-4-methoxy-9-methyl-2,3-dihydro-furo[2,3-b]quinolinium; iodide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-isopropyl-4-methoxy-9-methyl-2,3-dihydro-furo[2,3-b]quinolinium; iodide(98468-19-0)
• EPA Substance Registry System: 2-isopropyl-4-methoxy-9-methyl-2,3-dihydro-furo[2,3-b]quinolinium; iodide(98468-19-0)

Safety Data

• Hazardous Substances Data: 98468-19-0(Hazardous Substances Data)

Upstream product

• 35410-57-2 2-isopropyl-4-methoxyfuro[2,3-b]quinoline 
• 7282-19-1 atanine 
• 19765-56-1 2-isopropyl-4-methoxy-2,3-dihydro-furo[2,3-b]quinoline 
• 74-88-4 methyl iodide 

Relevant articles and documents

Quinoline alkaloids: Synthesis of pyrano[2,3,-b]quinolines, khaplofoline, lunacrine, and demethoxylunacrine

Polyphosphoric acid (PPA)-catalyzed cyclization of 2-ono-3- vinylquinolinecarboxylic acid (1) yielded 3,4-dihydro-2,2-dimethyl-2H- pyrano[2,3-b]quinoline (4). The same reaction of 4-methoxy-2-oxo-3- vinylquinolinecarboxylic acid (1g) afforded 4-methoxy-2,2-dimethylpyrano[2,3- b]-quinoline (4g), which on hydrolysis with ethanolic hydrochloric acid gave khaplofoline (5). The Prevost reaction of 4-methoxy-3-prenylquinolin-2-one (6) using I2/HgO in acetic acid yielded 4-methoxy-2-isopropylfuro[2,3- b]quinoline (7). Compound 7 on reduction with H2/Pd-C followed by N- methylation and de-O-methylation afforded lunacrine (10a). A similar reaction sequence on 6b gave demethoxylunacrine (10b).