98556-40-2Relevant articles and documents
Design and stereoselective synthesis of novel β-lactone and β-lactams as potent anticancer agents on breast cancer cells
Rashidi, Mahnoosh,Islami, Mohammad Reza,Esmaeili-Mahani, Saeed
, p. 835 - 841 (2018)
To produce a novel class of anticancer compounds, an efficient method for synthesizing novel β-lactone and β-lactam frameworks was developed based on the reaction of a new ketene with C=O and C=N bonds. Functionalized 2-azetidinones were efficiently synthesized by employing 2,4-dichlorophenoxylketene, which was generated in situ. The reaction of the ketene with aldehydes was not successful and in all cases except for 4-nitrobenzaldehyde, a rearranged dimer of the ketene was obtained as a lactone. Anticancer cellular activity of all new β-lactams and lactones on breast cancer cells was studied. All new synthesized compounds exhibited potential anticancer activity which may guarantee their future application in moderate chemotherapy.