98557-45-0

Basic information

• Product Name: 4-Methanesulfonyl-3-nitro-benzoyl chloride
• Synonyms: 4-Methanesulfonyl-3-nitro-benzoyl chloride
• CAS NO: 98557-45-0
• Molecular Weight: 263.658
• Mol File: 98557-45-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-Methanesulfonyl-3-nitro-benzoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methanesulfonyl-3-nitro-benzoyl chloride(98557-45-0)
• EPA Substance Registry System: 4-Methanesulfonyl-3-nitro-benzoyl chloride(98557-45-0)

Safety Data

• Hazardous Substances Data: 98557-45-0(Hazardous Substances Data)

Upstream product

• 81029-08-5 4-methylsulfonyl-3-nitro-benzoic acid 

Downstream Products

• 1034470-22-8 4-[1-(4-methylsulfonyl-3-nitrobenzoyl)piperidin-4-yl]benzonitrile 
• 299182-36-8 2-[(E)-2-[2-(isopropoxysulfonyl)-4-[4-(methylsulfonyl)-3-nitrobenzoyl]aminophenyl]ethenyl]-5-[4-[4-(methylthio)-3-(4-morpholinylsulfonyl)benzoyl]amino]benzenesulfonic acid, (1-methylethyl) ester 
• 194291-33-3 (4-Methanesulfonyl-3-nitro-phenyl)-phenyl-methanone 
• 194291-40-2 (3-Amino-4-methanesulfonyl-phenyl)-phenyl-methanone 
• 299182-30-2 5-[4-[(methylsulfonyl)-3-nitrobenzoyl]amino]-2-[(E)-2-[4-amino-2-sulfophenyl]ethenyl]benzenesulfonic acid, bis(1-methylethyl) ester 

Relevant articles and documents

SULFONAMIDE DERIVATIVES FOR THERAPEUTIC USE AS FATTY ACID SYNTHASE INHIBITORS

A compound of formula (I) or a pharmaceutically acceptable salt thereof, processes for preparing such compounds, their use as Fatty Acid Synthase inhibitors, methods for their therapeutic use, particularly in the treatment of obesity and diabetes mellitus

Utility of Complementary Molecular Reactivity and Molecular Recognition (CMR/R) Technology and Polymer-Supported Reagents in the Solution-Phase Synthesis of Heterocyclic Carboxamides

The use of our recently reported chemical library purification strategy in the development of a herbicidal lead, N-(3-benzoylphenyl)-3-(1,1-dimethylethyl)-1-methyl-1H-pyrazole-5-carboxamide (3), is described. The approach applying fundamental properties of complementary molecular reactivity and molecular recognition (CMR/R) as the basis for a general purification strategy was utilized. Polymeric reagents were used in the synthesis to generate reactive species involved in product formation, and complementary molecular reactivity/molecular recognition polymer 8 (CMR/R polymer 8) was used in the solution-phase syntheses of building blocks, primary libraries, and lead refinement libraries. An extension of the CMR/R methodology was applied, utilizing a sequestration enabling reagent (SER), transforming a reactant into an electrophilic species sequestrable by CMR/R polymer 8. This library purification strategy enabled rapid lead generation and lead refinement to afford herbicide 27o. The CMR/R solid-phase purification technique enabled a simple, general, and powerful protocol, eliminating the usual tedious and time-consuming methods required for solution-phase product purification. The result was the synthesis of hundreds of compounds, prepared in a relatively short time, leading to a compound with a 4-fold improvement in herbicidal activity over the initial lead.