98612-93-2

Basic information

• Product Name: (4-BROMO-PHENYL)-PIPERIDIN-1-YL-METHANONE
• Synonyms: (4-BROMO-PHENYL)-PIPERIDIN-1-YL-METHANONE;CHEMBRDG-BB 5264381;1-(4-BROMOBENZOYL)PIPERIDINE;1-(4-bromobenzoyl)piperidine(SALTDATA: FREE)
• CAS NO: 98612-93-2
• Molecular Formula: C₁₂H₁₄BrNO
• Molecular Weight: 268.15
• Product Categories: Piperidine
• Mol File: 98612-93-2.mol
• Article Data: 34

Chemical Properties

• Boiling Point: 378.6 °C at 760 mmHg
• Flash Point: 182.8 °C
• Appearance: /
• Density: 1.406 g/cm³
• Vapor Pressure: 6.2E-06mmHg at 25°C
• Refractive Index: 1.585
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (4-BROMO-PHENYL)-PIPERIDIN-1-YL-METHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: (4-BROMO-PHENYL)-PIPERIDIN-1-YL-METHANONE(98612-93-2)
• EPA Substance Registry System: (4-BROMO-PHENYL)-PIPERIDIN-1-YL-METHANONE(98612-93-2)

Safety Data

• Hazardous Substances Data: 98612-93-2(Hazardous Substances Data)

Usage

General Description

(4-BROMO-PHENYL)-PIPERIDIN-1-YL-METHANONE is a chemical compound that consists of a piperidine ring with a bromo-phenyl group and a methanone functional group. It is commonly used as an intermediate in the synthesis of pharmaceuticals and organic compounds. (4-BROMO-PHENYL)-PIPERIDIN-1-YL-METHANONE has potential applications in the development of new medications and research in the field of medicinal chemistry. Its chemical properties make it a versatile building block for the creation of diverse compounds with various biological activities. Additionally, its structure and properties make it an important target for chemical synthesis and optimization in drug discovery and development.

InChI:InChI=1/C12H14BrNO/c13-11-6-4-10(5-7-11)12(15)14-8-2-1-3-9-14/h4-7H,1-3,8-9H2

Upstream product

• 110-89-4 piperidine 
• 586-75-4 4-chlorobenzoyl chloride 
• 98612-91-0 1-(4-bromobenzoyl)-3-(methylthio)pyrrolidin-2-one 
• 586-76-5 4-Bromobenzoic acid 
• 1122-91-4 4-bromo-benzaldehyde 
• 2591-86-8 N-Formylpiperidine 
• 873-75-6 4-bromobenzenemethanol 
• 2156-71-0 N-chloropiperidine 
• 35578-47-3 4,4'-dibromobenzil 
• 39229-12-4 4-bromobenzil 
• 106-38-7 para-bromotoluene 
• 5467-74-3 4-Bromophenylboronic acid 
• 1013-92-9 di(piperidin-1-yl)methanethione 
• 99-90-1 para-bromoacetophenone 

Downstream Products

• 178162-69-1 1-(4-bromobenzyl)piperidine 
• 210961-92-5 4-(piperidine-1-carbonyl)benzoic acid 
• 938043-31-3 piperidin-1-yl-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-methanone 
• 1610537-65-9 (E)-(5-bromo-3-(1,2-diphenylvinyl)pyridin-2-yl)(piperidin-1-yl)methanone 

Relevant articles and documents

Photocatalytic aldehydes/alcohols/toluenes oxidative amidation over bifunctional Pd/MOFs: Effect of Fe-O clusters and Lewis acid sites

Heterogeneous photocatalytic organic synthesis is fascinating because of the utilization of ubiquitous solar light for chemical transformations. Here, three Fe-MOFs with different Fe-O clusters, Lewis acid sites and morphologies were synthesized through coordination structure engineering. Pd/Fe-MOFs nanocomposites were used to challenge the amide bond green synthesis with visible light. Pd/MIL-101(Fe) exhibited the best photocatalytic performance due to the easily excited Fe3-μ3-oxo clusters for light absorption, the efficient photogenerated carriers separation and migration, the large amount of Lewis acid sites based aldehydes and amines condensation promotion and the efficient O2 reduction to superoxide radicals over photogenerated electron-rich Pd NPs. Various aldehydes, alcohols and toluenes could be transformed to amide compounds with amines over Pd/MIL-101(Fe) with just oxygen or air as the green oxidant and water as the by-product. One-pot C–C cross-coupling and photo-redox C–N coupling cascade reactions could also be achieved over Pd/MIL-101(Fe). This work shed light on the efficient and sustainable amide bonds synthesis.

NaI-mediated oxidative amidation of benzyl alcohols/aromatic aldehydes to benzamides via electrochemical reaction

In this research, we have developed a mild electrochemical process for oxidative amidation of benzyl alcohols/aromatic aldehydes with cyclic amines into the corresponding benzamides. This electroorganic synthetic method proceeds using NaI as a redox mediator under ambient temperature in undivided cell, providing more than 25 examples of amide products in moderate to good yields. The benefits of this reaction include one-pot synthesis, open air condition, proceed in aqueous media and no requirement of external conducting salt, base and oxidant.

N2-carbamylaryl-2-aminopyrimidine derivative and medical application thereof

The invention provides an N2-carbamylaryl-2-aminopyrimidine derivative and a medical application thereof. The N2-carbamylaryl-2-aminopyrimidine derivative provided by the invention comprises an optical isomer of the N2-carbamylaryl-2-aminopyrimidine derivative and pharmaceutically acceptable salt thereof. Pharmacodynamic research shows that the traditional Chinese medicine composition has no toxicor side effect, the compound has an FLT3 inhibitory activity. The proliferation inhibition activity is realized on various leukemia cell strains; a medium inhibition effect is achieved on breast cancer cells; moreover, the polypeptide is effective for multiple mutations of AML, such as internal tandem repeat mutation of a near-membrane structural domain and D835 point mutation of an activated ring in a kinase structural domain, almost has no inhibition effect on c-KIT, can overcome drug resistance brought by clinical point mutation, can reduce toxic and side effects of bone marrow inhibition,and can be applied to preparation of antitumor drugs. The structures of the general formulas Ia and Ib of the N2-carbamylaryl-2-aminopyrimidine derivative are shown in the specification,