98642-44-5Relevant articles and documents
RAPAFUCIN DERIVATIVE COMPOUNDS AND METHODS OF USE THEREOF
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Paragraph 0520, (2021/04/02)
The present disclosure provides macrocyclic compounds inspired by the immunophilin ligand family of natural products FK506 and rapamycin. The generation of a Rapafucin library of macrocyles that contain FK506 and rapamycin binding domains should have grea
PRODRUG OF NITROXOLINE AND USE THEREOF
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Page/Page column 113-114, (2021/08/24)
The present invention relates to the prodrug of nitroxoline and use thereof. Specifically, the present invention relates to a compound of formula (I) or the pharmaceutically acceptable salt thereof, a preparation method thereof, a pharmaceutical composition comprising the same, as well as a use thereof in anti-infective and anti-tumor drugs. The compound of formula (I) has better pharmacokinetic parameters such as water solubility, blood concentration or half-life relative to nitroxoline. The compound of formula (I) can reduce the number of administrations, and has the possibility of being applied in other fields than the urinary tract field. The definition of each group in formula (I) is as defined in the description.
HETEROBIFUNCTIONAL MOLECULES AS TEAD INHIBITORS
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Paragraph 0263-0264; 0371-0372, (2021/09/11)
The invention relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.