98714-70-6

Basic information

• Product Name: L-Valine, N-[N-[(1,1-dimethylethoxy)carbonyl]-L-seryl]-, phenylmethyl ester
• CAS NO: 98714-70-6
• Molecular Formula: C20H30N2O6
• Molecular Weight: 394.468
• Mol File: 98714-70-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: L-Valine, N-[N-[(1,1-dimethylethoxy)carbonyl]-L-seryl]-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Valine, N-[N-[(1,1-dimethylethoxy)carbonyl]-L-seryl]-, phenylmethyl ester(98714-70-6)
• EPA Substance Registry System: L-Valine, N-[N-[(1,1-dimethylethoxy)carbonyl]-L-seryl]-, phenylmethyl ester(98714-70-6)

Safety Data

• Hazardous Substances Data: 98714-70-6(Hazardous Substances Data)

Upstream product

• 3262-72-4 (S)-N-(tert-butoxycarbonyl)serine 
• 65138-05-8 (S)-2-hydroxy-3-methylbutyric acid benzyl ester 
• 2462-34-2 L-valine benzyl ester hydrochloride 

Downstream Products

• 1158995-24-4 N-tert-butoxycarbonyl-O-benzyl-L-seryl-L-valyl-L-valyl-glycyl-glycine methyl ester 

Relevant articles and documents

Design, synthesis and biological evaluation of dipeptides as novel non-covalent 20S proteasome inhibitors

Based on the interaction modes of the natural 20S proteasome inhibitors TMC-95A, we have previously discovered a dipeptide 1. To explore the SAR around compound 1, we designed and synthesized a series of dipeptides (8–38) with a fragment-based strategy. Among them, nine compounds showed significant inhibitory activities against the chymotrypsin-like activity of human 20S proteasome with IC50 values at the submicromolar level, which were comparable or even superior to the parent compound 1. Meanwhile, they displayed no significant inhibition against trypsin-like and caspase-like activities of 20S proteasome. The results suggested the feasibility to design dipeptides as novel and potent 20S proteasome inhibitors. (Figure presented.).

2-Chloro-4,6-dimethoxy-1,3,5-triazine. A new coupling reagent for peptide synthesis

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