98751-77-0 Usage
Description
[3S,3aα,7aα,(-)]-3a,6,7,7a-Tetrahydro-6β-hydroxy-3α-[(benzoyloxy)methyl]-6-methylbenzofuran-2,5(3H,4H)-dione, commonly known as Rapamycin, is a naturally occurring compound derived from the bacterium Streptomyces hygroscopicus. It possesses immunosuppressant and antiproliferative properties, making it a versatile pharmaceutical agent for treating a range of medical conditions.
Uses
Used in Transplant Medicine:
Rapamycin is used as an immunosuppressant agent for preventing organ transplant rejection. Its ability to inhibit the activity of the mammalian target of rapamycin (mTOR) protein kinase helps in reducing the immune response and promoting the acceptance of transplanted organs.
Used in Oncology:
Rapamycin is utilized as an anti-cancer agent for treating certain types of cancer. Its antiproliferative properties help in controlling the growth and proliferation of cancer cells, making it a potential therapeutic option for cancer treatment.
Used in Autoimmune Disease Treatment:
Rapamycin is employed as a treatment for various autoimmune diseases. Its immunosuppressive effects help in managing the overactive immune response associated with these conditions, providing relief from symptoms and slowing disease progression.
Used in Anti-Aging Research:
Rapamycin is being studied for its potential anti-aging effects and its ability to extend lifespan in various organisms. Its ability to regulate cell growth, proliferation, and survival through the inhibition of mTOR may contribute to its anti-aging properties.
Used in Neurodegenerative and Metabolic Disorder Treatment:
Rapamycin has shown potential in treating neurodegenerative diseases and metabolic disorders. Its ability to modulate cellular processes and pathways involved in these conditions makes it a promising therapeutic candidate for further research and development.
Check Digit Verification of cas no
The CAS Registry Mumber 98751-77-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,8,7,5 and 1 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 98751-77:
(7*9)+(6*8)+(5*7)+(4*5)+(3*1)+(2*7)+(1*7)=190
190 % 10 = 0
So 98751-77-0 is a valid CAS Registry Number.
98751-77-0Relevant articles and documents
Enantiospecific Synthesis of (+)-Paeonilactone C and (+)-Paeoniflorigenone from R-(-)-Carvone
Hatakeyama, Susumi,Kawamura, Mitsuhiro,Takano, Seiichi,Irie, Hiroshi
, p. 7993 - 7996 (2007/10/02)
The first total syntheses of (+)-paeonilactone C and (+)-paeoniflorigenone, representative monoterpenes of Paeoniae Radix, have been accomplished starting with R-(-)-carvone via lipase catalyzed highly diastereoselective enzymatic acetylation.The latter synthesis also means the first total synthesis of (+)-paeonisuffral, a new monoterpene recently isolated from Moutan Cortex.
